FREQUENCY SWEPT ULTRASOUND OPTICAL TOMOGRAPHY OF BREAST

描述(改编自申请人摘要)：申请人建议 基于新型超声调制光学系统的乳腺成像研究 断层扫描技术提供了一种非侵入性、非电离性、廉价的 乳腺癌早期检测的诊断工具。聚焦的超声波 WAVE定义了成像分辨率，克服了WAVE的局部性差 生物组织中由光的强烈散射引起的光 纸巾。肿瘤的超声调制光信号具有 早期发现乳腺癌的可能性以及评估和 监测治疗，因为光学特性与组织相关 化学成分及其分子构象。最近的研究表明 证明了埋藏在稠密混浊介质中的物体(如生物 组织)可以使用超声调制的光学层析成像。 聚焦到组织中的超声波调制通过的激光 焦点。超声调制的光信号反射局部 焦点处的机械和光学性质。被掩埋的物体是 通过扫描设备并检测 超声调制的光信号。到目前为止，申请者已经实现了 5厘米厚的组织体模中的1毫米成像分辨率。这项研究已经 表明了乳房成像和临床应用的潜力 癌症检测。机械性能和光学性能的差异 正常组织和异常组织之间的区别将是检测肿瘤的基础 使用这种技术。提高单频成像质量的方法 超声波调制的光学图像，申请人设计了一种精致的 成像技术：扫频超声调制光学层析成像， 这最大限度地减少了来自超声波焦点外的干扰。 建议的扫频研究的具体目标 超声调制光学层析成像包括：1)对对象进行成像 组织幻影；2)3.在生物组织中进行肿瘤体外成像； 乳腺肿瘤的活体成像和血红蛋白氧合测定 肿瘤的饱和度。

DESCRIPTION (Adapted from Applicant's Abstract): The applicants proposed to investigate breast imaging based on the novel ultrasound-modulated optical tomography technique to provide a non-invasive, nonionizing, inexpensive diagnostic tool for early breast cancer detection. A focused ultrasonic wave defines the imaging resolution and overcomes the poor localization of light in biological tissues caused by the strong scattering of light in tissues. The ultrasound-modulated optical signal of the tumors has the potential for early detection of breast cancers and for assessing and monitoring treatment, because optical properties are related to tissue constituents and their molecular conformations. Recent studies have demonstrated that objects buried in dense turbid media (such as biological tissues) can be imaged using ultrasound-modulated optical tomography. Ultrasound focused into the tissue modulates the laser light passing through the focal spot. The ultrasound-modulated optical signal reflects the local mechanical and optical properties at the focal spot. Buried objects are located by scanning the device and detecting alterations of the ultrasound-modulated optical signal. So far, the applicants have achieved 1-mm imaging resolution in a 5-cm thick tissue phantom. This research has indicated the potential for clinical application in breast imaging and cancer detection. The differences in mechanical and optical properties between normal and abnormal tissues will be the basis of detecting tumors using this technique. To improve the imaging quality of single-frequency ultrasound-modulated optical images, the applicants have designed a refined imaging technique: frequency-swept ultrasound-modulated optical tomography, which minimizes the interference originating from off the ultrasonic focus. The specific aims of the proposed studies on frequency-swept ultrasound-modulate optical tomography include: 1.) Imaging objects in tissue phantoms; 2.) Imaging tumors in biological tissue in vitro; and 3.) Imaging breast tumors in vivo and measuring hemoglobin oxygenation saturation of tumors.