GENETIC DETERMINANTS OF HIGH BP IN THREE RACIAL GROUPS

我们网络提案的具体目标是从基因本地化出发， 以确定候选功能DNA序列在这些 基因，以估计这种DNA变异对风险的贡献 EHYT的。首先，我们将使用连锁分析来定位基因 在三个种族群体中导致EHYT的风险：非洲人- 来自密西西比州杰克逊市的美国人，来自德克萨斯州斯塔尔县和墨西哥的美国人 来自明尼苏达州罗切斯特的非西班牙裔白人。拟议的连锁分析 将利用一系列广泛的 候选基因和大量的匿名标记 基因组。我们将使用多个双等位基因序列多态性和 分支分析开始识别候选功能序列 基因内的变异导致个体间的差异 血压水平和EHYT状态。最后，我们将评估 候选功能DNA序列变异预测EHYT状态的研究 三个种族：来自密西西比州杰克逊的非裔美国人，墨西哥人- 来自德克萨斯州斯塔尔县的美国人和来自罗切斯特的非西班牙裔白人， Mn.

The specific aims of our Network proposal proceed from localizing genes, to identifying candidate functional DNA sequence variation within these genes, to estimating the contribution of this DNA variation to the risk of EHYT. First, we will use linkage analysis to localize genes contributing to the risk of EHYT in three racial groups: African- Americans from Jackson, MS, Mexican-Americans from Starr County, TX, and Non-Hispanic Whites from Rochester, MN. The proposed linkage analyses will take advantage of the availability of both an extensive array of candidate genes and a large number of anonymous markers throughout the genome. We will use multiple diallelic sequence polymorphisms and cladistic analyses to begin to identify candIdate functional sequence variation within a gene contributing to interindividual differences in BP levels and EHYT status. Finally, we will evaluate the ability of the candidate functional DNA sequence variation to predict EHYT status in three racial groups: African-Americans from Jackson, MS, Mexican- Americans from Starr County, TX, and Non-Hispanic Whites from Rochester, MN.