MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS

迈阿密大学申请的主要目的是 继续参加合作社第三个周期 多中心新生儿研究网络。 网络的目标是 目前由12所大学新生儿中心组成， 治疗和管理策略的安全性和有效性， 新生儿，尤其是低出生体重儿。 人们希望 这个已经建立的、正在进行的网络将促进这种研究工作 通过提供大量的母亲和婴儿进行研究， 和一个成熟的研究团队，准备实施多个项目 同步 迈阿密大学积极参与其中 网络在过去10年提供专业知识，领导和 以合作精神提升网络的目标。 司 新生儿医学拥有庞大的、多样化的、多文化的人群， 临床，实验室和研究设施，以及主管和 敬业的员工。 有着悠久的成功参与历史 在多中心临床试验以及个体研究者中 启动的项目。 以前的主要合作临床试验 包括参与产前糖皮质激素的使用 为了预防呼吸窘迫综合征（NHLBI）， 通气研究（NHLBI）和婴儿健康与发展计划 （Robert Wood约翰逊，NICHD，MCH，皮尤基金会）。 虽然正常 新生儿出生人口在过去几年中大幅下降， 多年来，对新生儿的特殊护理效果甚微 人口 这是由于成功的分流复杂，高风险， 以及越来越多的非常小的，不成熟的婴儿转诊 来自该地区多个二级单位的转介， 加勒比海、中美洲和南美洲。 因此，该程序绘制 每个地区有40 000多名产妇和婴儿， 年 新生儿特殊护理中心的工作人员人数超过250人， 包括全职新生儿呼吸治疗师和新生儿 药剂师，以及护士，执业护士，临床主治医生， 研究员、住院医生和法医。 有八个委员会认证 和1名董事会合格的兽医师在该计划谁拥有专业知识 心肺生理学，发育医学，血液学， 免疫学和传染病，中枢神经系统， 滥用药物对胎儿和新生儿的影响 一个非常大的，全面的 指导多学科临床随访和干预计划 被私家侦探这一提交。 除了临床承诺， 这个项目，在过去的几年里，大学设计和 为该项目完成了一个大型的临床和办公区。 地面 上个月，一座12层的儿科研究大楼被打破， 医学校园与特定的空间分配给正在进行的 该研究项目的实施，临床和 行政上。 迈阿密大学作出了重大承诺， 这一重要的临床网络，并真诚地努力继续 在未来5年的周期内，这种合作，试图解决 复杂和重要的进展，在诊断和治疗的 新生儿

The primary objective of this application by the University of Miami is for continued participation in the third cycle of the Cooperative Multicenter Neonatal Research Network. The goal of the network, which is currently made up of 12 university neonatal centers is to investigate the safety and efficacy of treatment and management strategies in the care of newborn infants, particularly those of low-birth-weight. It is hoped that this established, on-going network will facilitate such research efforts by providing large populations of mothers and infants available for study and an established research team ready to implement multiple projects simultaneously. The University of Miami has actively participated in this network for the past 10 years providing expertise, leadership and a cooperative spirit to enhance the network's goals. The Division of Neonatology has a large, diverse, multi-cultural population, outstanding clinical, laboratory and research facilities, as well as competent and dedicated personnel. There is a long history of successful participation in multicenter clinical trials as well as individual investigator initiated projects. Previous major collaborative clinical trials have included participation in the administration of prenatal glucocorticoids to prevent respiratory distress syndrome (NHLBI), the high frequency ventilation study (NHLBI) and the infant health and development program (Robert Wood Johnson, NICHD, MCH, Pew Foundation). Although the normal newborn birth population has decreased significantly over the last several years, there has been little effect on the neonatal special care population. This is due to successful triage of complicated, high-risk mothers as well as increased referrals of very small, immature infants from multiple level II units in the district and additional referrals from the Caribbean, Central and South America. Hence, the program draws mothers and infants from an area encompassing over 40,000 deliveries per year. The staff of the neonatal special care center numbers over 250 and includes full-time neonatal respiratory therapists and neonatal pharmacists, as well as nurses, nurse practitioners, clinical attendings, fellows, residents and neonatologists. There are eight board certified and 1 board eligible neonatologists within the program who have expertise in cardio-pulmonary physiology, developmental medicine, hematology, immunology and infectious disease, central nervous system, and the effects of substance abuse on the fetus and newborn. A very large, comprehensive multidisciplinary clinical follow-up and intervention program is directed by the P.I. of this submission. In addition to its clinical commitment to this project, over the last several years the University has designed and finished a large clinical and office area for this project. Ground was broken within the last month for a 12 story pediatric research tower on the medical campus with specific space allocated to the on-going implementation of this research project, both clinically and administratively. The University of Miami has made a major commitment to this important clinical network and is sincere in its effort to continue this collaboration over the next 5 year cycle, attempting to address complex and important advances in the diagnosis and treatment of the newborn.