SLEEP DEPRIVATION AND ALCOHOL EFFECTS IN MARIJUANA USERS

描述：（申请人摘要） 毒品和酒精是导致车祸的药物， 单独使用和组合使用。对成年人来说， 深夜吸毒会剥夺睡眠虽然许多事故后的血液 分析表明大麻和酒精有关，没有对照实验研究 量化了睡眠对行为和主观的综合影响 大麻或大麻酒精混合物的剥夺。的 该项目的新奇在于其使用受控的睡眠实验室测量， 驾驶模拟器，计算机化的身体摇摆测量， 注意力和自我报告情绪量表来评估睡眠的各种方式 剥夺和酒精损害了使用大麻的司机。该项目 三个具体目标。第一个目标是量化酒精如何改变 大麻对情绪、平衡、注意力和模拟汽车的影响 开车第二个目标是量化部分睡眠剥夺如何改变 大麻对这些措施的影响。第三个目标是量化 睡眠剥夺对大麻酒精混合物的影响。三项研究 建议使用随机安慰剂对照设计。在每项研究中， 受试者将吸食大麻香烟（0，1.77或3.95% Δ 9 THC）， 两个或三个不同的条件。研究1将操纵同时剂量的 酒精（0.0、0.5或0.8 g/kg）。研究2将操纵会前睡眠 小时（8比3）。研究3将增加对酒精的期望和体验， 在研究2的条件下，每个受试者饮用一定剂量的酒精（0.0， 0.5或0.8 g/kg）。研究的因变量包括 1)通过计算机动态姿势描记术测量的身体摇摆，2）主观 影响量表（情绪状态和视觉模拟量表），3）Stroop 注意力分散的颜色测试，以及4）驾驶中的制动潜伏期 模拟器通过澄清大麻的单独和综合作用， 酒精和睡眠剥夺对这些生态有效的措施， 调查结果将有助于预防与毒品有关的公路死亡事故。

DESCRIPTION: (Applicant's Abstract) Marijuana and alcohol are drugs that contribute to automobile accidents when used separately and in combination. A further danger to adults who drive after late-night drug use is sleep deprivation. While many post-accident blood analyses have implicated marijuana and alcohol, no controlled empirical studies have quantified the combined behavioral and subjective effects of sleep deprivation with either marijuana or marijuana-alcohol combinations. The novelty of this project is its use of controlled Sleep Laboratory measurements, a driving simulator, computerized body sway measurement, a test of divided attention, and self-report mood scales to assess the various ways sleep deprivation and alcohol impair a driver who uses marijuana. The project has three specific aims. The first aim is to quantify how alcohol alters the effects of marijuana on mood, equilibrium, attention, and simulated automobile driving. The second aim is to quantify how partial sleep deprivation alters the effects of marijuana on these measures. The third aim is to quantify the effects of sleep deprivation on marijuana-alcohol combinations. Three studies using randomized placebo controlled designs are proposed. In each study, subjects will smoke a marijuana cigarette (0, 1.77, or 3.95% delta 9 THC) in two or three separate conditions. Study 1 will manipulate a concurrent dose of alcohol (0.0, 0.5, or 0.8 g/kg). Study 2 will manipulate pre-session sleep hours (8 vs. 3). Study 3 will add the expectation and experience of alcohol to the conditions of Study 2, with each subject drinking a dose of alcohol (0.0, 0.5, or 0.8 g/kg) before testing. The dependent variables to be studied include 1) body sway as measured by computerized dynamic posturography, 2) subjective effects scales (Profile of Mood States and Visual Analog Scales), 3) the Stroop Color Test of divided attention, and 4) brake latency within the driving simulator. By clarifying the separate and combined effects of marijuana, alcohol, and sleep deprivation on these ecologically valid measures, the results will contribute to the prevention of drug-related highway fatalities.