Detection and viability of waterborne pathogens using a gut-on-chip

该项目旨在解决水务公司的一个重大问题。微生物病原体隐孢子虫、诺如病毒和腺病毒是发达国家饮用水的主要公共卫生问题。由于缺乏快速、可靠的检测方法和对这些病原体的活力测定，水监测受到限制。本项目将首次使用新型肠道芯片开发隐孢子虫、诺如病毒和腺病毒的快速感染性检测方法。显著的好处包括改进诊断和水消毒分析，改进水处理和降低成本，具有全球影响。

This project aims to resolve a significant problem for water utilities. Microbial pathogens Cryptosporidium, norovirus and adenovirus are the main public health concern for drinking water in developed nations. Water monitoring is limited by the lack of fast, reliable detection methods and viability assays for these pathogens. This project will use a novel gut-on-a-chip to develop for the first time rapid infectivity assays for Cryptosporidium, norovirus and adenovirus. Significant benefits include improved diagnostics and water disinfection assays, improved water treatment and reduced costs with global impact.