Advanced Knee ASL Imaging at 7T

7T 先进膝关节 ASL 成像

• 批准号: 10658674
• 负责人: Xiufeng Li
• 金额: $ 36.92万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10658674
• 关键词: Address; Adipocytes; Adolescent; Adult; Affect; Algorithms; Blood; Blood capillaries; Blood flow; Bone Development; Bone Marrow; Brain; Clinical; Clinical Research; Communities; Degenerative polyarthritis; Development; Diagnostic; Disease; Disease Progression; Echo-Planar Imaging; Etiology; Family; Functional disorder; Goals; Healthcare; Image; Knee; Knowledge; Lesion; Libraries; Logistic Regressions; Magnetic Resonance Imaging; Measures; Methodology; Methods; Modeling; Monitor; Noise; Nomograms; Osteochondritis Dissecans; Patients; Performance; Perfusion; Physiologic pulse; Physiological; Physiology; Play; Population; RF coil; ROC Curve; Research; Role; Safety; Signal Transduction; Slice; Speed; System; Technology; Therapy Evaluation; Time; Tissue Viability; Tissues; Uncertainty; arterial spin labeling; bone; bone repair; cohort; design; experience; healing; human model; imaging modality; imaging platform; imaging study; improved; insight; magnetic field; new technology; next generation; novel; prognostic performance; research study; response; safety assessment; skeletal disorder; software systems; tool; transmission process; treatment response; virtual; virtual model

Abstract Bone marrow perfusion can provide essential knowledge about bone physiology, improve our understanding of disease etiology and pathophysiology, assist the differentiation between normal and abnormal bone marrow, and assess the response to prescribed therapies. Arterial spin labeling (ASL) magnetic resonance imaging (MRI), as a noninvasive and non-contrast-enhanced approach, is well suited for longitudinal monitoring of disease progression and routine evaluation of therapy response. But as revealed by our recent studies, there exist technical challenges (e.g., low signal-to-noise (SNR) ratio due to significantly low perfusion in epiphyseal yellow bone marrow mainly consisting of fat cells with a sparse network of capillaries), and methodological limitations (e.g., single slice coverage and impractically long acquisition time for multi-slice imaging at 3T), hampering routine application of ASL imaging in the knee. Ultrahigh (≥7T) magnetic field can specifically benefit ASL imaging and overcome these challenges by increasing SNR, prolonging blood and tissue T1, and improving parallel imaging performance. However, the current clinically approved single-transmit MRI system and associated imaging methods are incapable of managing the transmit B1 (B1+) fields needed to realize the promised improvement in imaging quality, reliability, and robustness of 7T while existing RF coils are unable to provide adequate B1+ coverage for optimal ASL imaging. Our long-term goal is to develop and improve UHF imaging methods to better facilitate scientific research and clinical studies to improve the management of skeletal diseases and patient healthcare. The rationale is that the existing technical challenges for UHF imaging, including ASL, can be overcome or mitigated, ultimately to realize UHF potentials with promised benefits and superior imaging ability. The objective of this proposal is to develop an optimized, safe, and efficient pTx platform for knee ASL imaging (Aim 1), to develop and optimize pTx-integrated knee ASL imaging methods (Aim 2) and to explore their clinical potentials via studies with a cohort of JOCD patients, an ideal testbed for the developed methodologies. Accomplishing these aims will enable us to fully explore and utilize pTx potentials to overcome the existing technical challenges for knee ASL imaging at 7T. Once developed and optimized, the ASL methods, along with the pTx knee imaging platform, will provide clinicians and research community a powerful tool to enrich our insights into disease etiology and pathophysiology and improve the management of not only JOCD but also various impactful common knee diseases (e.g., osteoarthritis). Novel knowledge and experience from our pioneering development will speed up the maturity of new technology toward early approval of the next generation of clinical UHF MRI systems.

摘要 骨髓灌流可以提供有关骨生理的基本知识，提高我们对 疾病病因和病理生理学，有助于区分正常和异常的骨髓， 并评估对处方疗法的反应。动脉自旋标记(ASL)磁共振成像 (MRI)作为一种无创、无对比增强的方法，非常适合于对 疾病进展和治疗反应的常规评估。但正如我们最近的研究所揭示的，在那里 存在技术挑战(例如，由于骨骺中的低灌注量而导致的低信噪比 黄骨髓，主要由脂肪细胞和稀疏的毛细血管网络组成)，以及方法学 限制(例如，单切片覆盖和在3T的多切片成像的不切实际的长采集时间)， 妨碍了ASL成像在膝关节的常规应用。超高(≥7T)磁场可以特别受益 ASL成像，并通过提高SNR、延长血液和组织T1并改善 并行成像性能。然而，目前临床批准的单次传输MRI系统和 相关成像方法不能管理实现以下目标所需的发射B1(B1+)场 承诺改善7T的成像质量、可靠性和稳健性，而现有的射频线圈无法 提供足够的B1+覆盖范围，以实现最佳的ASL成像。我们的长期目标是发展和完善超高频 影像方法，更好地促进科学研究和临床研究，以改善骨骼的管理 疾病和病人保健。其基本原理是，超高频成像的现有技术挑战， 包括ASL，可以克服或缓解，最终实现超高频潜力，并承诺的好处和 卓越的成像能力。这项建议的目标是开发一个优化、安全和高效的PTX平台 对于膝关节ASL成像(目标1)，开发和优化PTX集成的膝关节ASL成像方法(目标2)和 通过对一群JOCD患者的研究来发掘他们的临床潜力，这是开发的理想试验床 方法论。实现这些目标将使我们能够充分挖掘和利用PTX潜力来克服 7T下膝关节ASL成像存在的技术挑战。一旦开发和优化，ASL方法， 与PTX膝关节成像平台一起，将为临床医生和研究社区提供一个强大的工具 丰富我们对疾病病因学和病理生理学的见解，并改善对JOCD的管理 而且还有各种常见的膝关节疾病(如骨性关节炎)。新奇的知识和经验来自 我们的开创性开发将加快新技术的成熟，朝着下一项技术的早日批准迈进 一代临床超高频磁共振成像系统。