MECHANISMS OF ACOUSTIC PERCEPTION AND ORIENTATION

描述：该实验室研究的总体目标是 回声定位和定位的行为、生理和解剖学相关性 在留着胡子的蝙蝠里听到。这项提议侧重于两个主要主题： 通过OC传出和内耳3D成像控制耳蜗。 它有五个具体目标：1.监控MOC活动和引发的变化 在回声定位过程中的耳蜗力学。这包括演示 时相活动与脉冲的发射和对 回声和主音活动与总的声学输入随时间变化的关系。 2.展示MOC活动、声音知觉、 回声定位行为(DS补偿)与神经相关 回声定位(例如调谐曲线锐度)。3.确定声学 导致MOC击穿的刺激参数诱导的抑制 并证明这一故障是由于 在ACh和GABA的耳蜗中，两种已知的递质相互作用 调节传出活动。4.建立外围课程， LOC纤维和终末在不同环境中的分布和排列 耳蜗区的功能区(例如，60-90 khz的中心凹区域等 广泛调谐的片段)。5.完成大连湾核磁共振图像的采集 蝙蝠和其他哺乳动物的耳蜗学建模探索(有限元 振动模式的分析-有限元分析)，给定 由MRM重建的耳蜗术。

DESCRIPTION: The overall goal of the laboratory's research is the behavioral, physiological, and anatomical correlates of echolocation and hearing in the mustached bat. This proposal focuses on two main themes: control of the cochlea by OC efferents and 3D imaging of the inner ear. There are five specific aims: 1. Monitor MOC activity and induced changes in cochlear mechanics during echolocation. This includes the demonstration of phasic activity in relation to the emission of pulses and perception of echoes and tonic activity in relation to the total acoustic input over time. 2. Demonstrate links between MOC activity, acoustic perception, echolocation behavior (DS compensation) and neural correlates of echolocation (e.g. tuning curve sharpness). 3. Determine the acoustic stimulus parameters that cause the breakdown of MOC induced suppression of cochlear damping and demonstrate that this breakdown is due to the interaction, w/in the cochlea of ACh and GABA, the two transmitters known to mediate efferent activity. 4. Establish the peripheral course, distribution, and arrangement of LOC fibers and terminals in different functional areas of the cochlea (e.g. 60 - 90 kHz foveal regions and more broadly-tuned segments). 5. Complete the collection of MRM images of the cochleae of bats and other mammals and explore the modeling (finite element analysis - FEA) of vibrational patterns, given the dimensions of the cochleae reconstructed from MRM.