SCHIZOPHRENIA--RELATED TRAITS

描述（改编自申请人摘要）： 精神分裂症的复发风险低，且非孟德尔模式 的传输。 虽然精神分裂症本身并不具有高度的渗透性， 与精神分裂症相关的特征，发生在一个更高的 精神分裂症患者亲属的死亡率可以作为有用的指标， 精神分裂症基因的连锁分析。 其中突出的 相关的特征是眼动追踪功能障碍，思维障碍， 颅面畸形以及与之相关的临床体征和症状 精神分裂症谱系 调查人员建议， 通过绘制这些更普遍的相关基因， 数量性状，而不是依赖于一种全有或全无的疾病， 表型。 因为这种策略将情感建立在具有 比精神分裂症更高的遗传信号，研究人员预计， 将增加关联分析的能力。 调查人员将使用 非参数和模型依赖的方法来测试在一个 样本包含160-208个同胞对组合。 他们将包括 Haseman-Elston方法的最新修改以及lod评分 分析. 他们将使用判别函数作为定量表型。 他们将扫描整个基因组，以寻找与个体之间联系的证据。 数量表型和数量表型的组合， 使用10 cM的图谱分型高度信息化的多等位基因标记，或 少 用于评估基因组结果的稳健统计方法 扫描将被开发。

DESCRIPTION (adapted from applicant's abstract): Linkage studies of schizophrenia are hampered by low recurrence risk and a non-Mendelian mode of transmission. Although schizophrenia itself is not highly penetrant, traits that are associated with schizophrenia and that occur at a higher rate in relatives of schizophrenics could serve as useful pointers to the gene(s) for schizophrenia in linkage analysis. Prominent among these associated traits are eye tracking dysfunction, thought disorder, craniofacial dysmorphology, and clinical signs and symptoms associated with the schizophrenia spectrum. The investigators propose to maximize discrimination among genotypes by mapping these more prevalent associated quantitative traits, rather than relying on an all-or-none disease phenotype. Because this strategy bases affectedness on traits that have a higher genetic signal than schizophrenia, the investigators expect that it will increase the power of linkage analysis. The investigators will use both nonparametric and model-dependent methods to test for linkage in a sample comprising 160-208 sibling pair combinations. They will include recent modifications of the Haseman-Elston method as well as lod score analysis. They will use discriminant functions as quantitative phenotypes. They will scan the entire genome for evidence of linkage to individual quantitative phenotypes and combinations of quantitative phenotypes by typing highly informative multi-allele markers, using a map of 10 cM or less. Robust statistical methods for evaluating the results of genomic scans will be developed.