BIOMARKERS OF LUNG CANCER SUSCEPTIBILITY IN MINORITIES

描述：(改编自《调查人员摘要》)肺癌是 是美国癌症死亡的主要原因。民族差异 在肺癌的发生和生存方面还没有充分的了解，并可能 反映了环境和遗传因素的影响。澄清 这些因素在极高和极低风险人群中的相互作用将 在制定新的干预和预防战略方面至关重要。这 研究重点是非裔美国人，他们背负着不成比例的 肺癌和发病率非常低的拉丁裔。调查人员表示 他们在休斯顿继续进行肺癌的生态遗传学研究， 将在大量人群中测试第一项研究的具体发现 在北加州的非洲裔美国人和拉美裔美国人，并将探索 基因座以前从未在少数族裔中研究过。他们会采集血液 采集样本并对来自每个民族的350例患者进行面对面采访 集团，通过北加州癌症中心(NCCC)快速确定 病例查明计划，以及同等数量的种族、年龄和 性别频率与通过随机数字拨号招募的对照组相匹配。他们 将建立一个DNA库并估计遗传疾病的流行率 细胞色素P-450基因(CYP1A1)和两种谷胱甘肽基因的多态性 S转移酶(GSTM1、GSTT1)、NAD(P)H：苯醌氧化还原酶(NQ01)和 两个N-乙酰转移酶(NAT1、NAT2)和XRCC1 DNA修复基因。这个 研究人员表示，以前这些特征与肺部的关联 高加索人或日本人的癌症不容易概括为 少数群体，而没有他们在这里提出的进一步的详细研究。vbl.使用 多个遗传标记是同时检测的一种高效手段 关于基因对癌症风险的贡献的几个假设。他们 进一步声明，一项特别独特的贡献将为 了解以下人群肺癌发病率显著较低的基础 拉丁裔人口；他们强调，他们的研究代表了唯一 在拉丁裔中进行的基于人口的同类研究。此外，他们还表示 这将是第二次基于人群的遗传流行病学 非洲裔美国人肺癌的研究；非洲裔美国男性 加州终生罹患肺癌的风险为11%。进一步指出， 关于吸烟和其他疾病的DNA库和全面的问卷数据 重要的风险因素也将被证明对继续研究 肺癌的遗传流行病学。

DESCRIPTION: (Adapted from Investigator's Abstract) Lung cancer is the leading cause of cancer mortality in the United States. Ethnic differences in lung cancer occurrence and survival are inadequately understood and may reflect both environmental and genetic influences. Elucidating the interplay of these factors in very high- and very low-risk populations will be crucial in developing novel intervention and prevention strategies. This study focuses on African-Americans who bear a disproportionate burden of lung cancer and Latinos who have very low rates. The investigators state that this continuation of their ecogenetics study of lung cancer in Houston, TX, will test specific findings from the first study in a large population of African-Americans and Latinos in Northern California and will explore gene loci never before studied in minorities. They will collect blood specimens and conduct in-person interviews with 350 cases from each ethnic group, identified through the Northern California Cancer Center (NCCC) rapid case ascertainment program, and an equal number of ethnicity-, age-, and sex-frequency matched controls recruited through random digit dialing. They will establish a DNA bank and estimate the prevalence of genetic polymorphisms in a cytochrome P-450 gene (CYP1A1), two glutathione S-transferases (GSTM1, GSTT1), the NAD(P)H:quinone oxidoreductase (NQ01) and two N-acetyl transferases (NAT1, NAT2), and the XRCC1 DNA repair gene. The investigators state that previous associations of these traits with lung cancer among Caucasians or Japanese are not readily generalizable to minorities without the further detailed study that they propose here. Using multiple genetic markers is a highly efficient means to simultaneously test several hypotheses concerning genetic contributions to cancer risk. They further state that an especially unique contribution will be laying the foundation to understand the markedly lower rates of lung cancer among Latino populations; they emphasize that their study represents the only population-based study of its kind among Latinos. Furthermore, they state that this will be only the second population-based genetic epidemiologic study of lung cancer in African-Americans; African-American men in California have an 11% lifetime risk of lung cancer. The further note that the DNA bank and comprehensive questionnaire data on smoking and other important risk factors also will prove invaluable for continuing studies of the genetic epidemiology of lung cancer.