IMPACT OF PAIN ON CEREBRAL BLOOD FLOW IN PRETERM INFANTS

描述（改编自研究者摘要）：当前研究 表明婴儿对疼痛的常见生理反应包括 心率、血压和颅内压升高，以及 氧饱和度下降。这些参数直接影响脑血 流动，从而增加了脑室内出血（IVH）的风险，这是一个重大问题 新生儿重症监护室发病和死亡的原因。的 本研究的目的是描述脑血流现象 速度作为对急性伤害性事件的反应，脚跟坚持， 包括足跟粘着过程的所有阶段。具体目的是比较 足跟贴压对脑血流速度的影响 非伤害性事件，脚跟准备。拟议的试点研究将有一个 随机双阶段、双治疗、交叉设计。婴儿将作为 他们自己的控制;每个婴儿都将接受两种治疗。20名受试者 将通过方便的抽样选择，然后随机分配到两个 组各组将因治疗顺序而异。观察将在 基线和每次治疗后6个时间点，共13例 观察每一个婴儿。

DESCRIPTION (As Adapted from the Investigator's Abstract): Current research demonstrate that common physiologic response to pain in infants include increased heart rate, blood pressure, and intracranial pressure, as well as decreased oxygen saturation. These parameters directly impact cerebral blood flow, thereby increasing the risk for intraventricular hemorrhage (IVH) a major cause of morbidity and mortality in the neonatal intensive care unit. The purpose of this research is to describe the phenomena of cerebral blood flow velocity as a response to an acute nocioceptive event, the heel stick, which includes all phases of a heel stick procedure. The specific aim is to compare the response in cerebral blood flow velocity of the heel stick with the non-nocioceptive event, heel prep. The proposed pilot study will have a randomized two-period, two-treatment, crossover design. Infants will serve as their own control; each infant will receive both treatments. Twenty subjects will be selected via a sample of convenience and then randomized to one of two groups. Groups will differ for order of treatment. Observations will be made at baseline and than at six time points following each treatment for a total of 13 observations for each infant.