FASEB CONFERENCE ON UBIQUITIN AND PROTEIN DEGRADATION

描述：(改编自申请者的摘要)会议的泛素和 “细胞内蛋白质降解”将于7月31日至8月5日举行， 1999年，在佛蒙特州萨克斯顿河的佛蒙特州学院会议中心。 本次会议由The Federation of the Federation赞助并提供部分资金 美国实验生物学学会(FASE B)，并已举行 自1989年以来每两年举行一次。这次会议是唯一一次定期举行的国际会议 主要讨论泛素的生物学和生物化学的会议。在这 申请：会议组织者要求为1999年的部分资金 会议。 保守的蛋白质泛素和作用于它的许多酶是 真核生物所必需的。泛素的生物学功能是通过以下途径实现的 它通过其C端的羧基与赖氨酸的共价结合 细胞蛋白质的残留物。人们对泛素最了解的功能是 一种以蛋白质为目标的信号，通过 26S蛋白酶体；降解性信号依赖于一个 底物结合的具有特定异肽结构的多泛素链。通过 设定关键调节蛋白的水平，泛素-蛋白酶体 降解途径控制着基本的细胞内过程，包括 细胞周期的进展和炎症反应的诱导。 泛素化也可以信号的命运，而不是以蛋白酶体为目标； 这些其他信号传递功能的机制才刚刚开始 明白了。此外，最近变得明显的是，一系列 泛素样蛋白(例如，Sumo-1/Smt3p)经历的代谢是 与泛素平行，但与泛素不同。这些分子似乎 作为共价信号，将它们的底物靶向于特定的 单元格内的位置。 上述主题是九个主题中要解决的问题之一 1999年会议的科学会议。将有7个普通航班 会议，每个会议包括五个特邀演讲；两个特别会议，每个会议 由七个演讲组成，将根据以下内容选择演讲 提交的摘要。后一位发言者的选择将特别注意。 更年轻的调查人员和令人兴奋的最新发展。此外，还有 将有两个海报会议。会议的规模很小，形式也很复杂， 旨在促进165名参与者之间的互动。

DESCRIPTION: (adapted from applicant's abstract) The conference 'Ubiquitin and Intracellular Protein Degradation' will be held from July 31 through August 5, 1999, at the Conference Center of the Vermont Academy in Saxton's River, VT. This meeting is sponsored and partially funded by the Federation of the American Societies for Experimental Biology (FASEB), and it has been held biennially since 1989. This conference is the only regularly-held international meeting devoted primarily to the biology and biochemistry of ubiquitin. In this application the conference organizers request partial funding for the 1999 conference. The conserved protein ubiquitin, and many of the enzymes which act upon it, are essential in eukaryotes. The biological functions of ubiquitin are mediated by its covalent attachment, through its C-terminal carboxyl group, to lysine residues of cellular proteins. The best-understood function of ubiquitin is that of a signal which targets proteins for ATP-dependent degradation by the 26S proteasome; degradative signaling depends upon the assembly of a substrate-bound polyubiquitin chain with a specific isopeptide structure. By setting the levels of key regulatory proteins, the ubiquitin-proteasome degradation pathway controls fundamental intracellular processes, including the progression of the cell cycle and the induction of the inflammatory response. Ubiquitination can also signal fates other than targeting to the proteasome; the mechanisms of these other signaling functions are only beginning to be understood. Moreover, it has recently become apparent that a set of ubiquitin-like proteins (e.g., Sumo-1/Smt3p) undergo a metabolism which is parallel to, but distinct from, that of ubiquitin. These molecules appear to function as covalent signals which target their substrates to specific locations within the cell. The aforementioned topics are among those to be addressed in the nine scientific sessions of the 1999 Conference. There will be seven regular sessions, each consisting of five invited talks; two special sessions, each consisting of seven talks, will feature presentations to be selected based on submitted abstracts. The latter speakers will be chosen with special attention to younger investigators and exciting recent developments. In addition, there will be two poster sessions. The small size of the conference, and its format, are designed to foster interactions among the 165 participants.