FASEB CONFERENCE--PROKARYOTIC TRANSCRIPTION INITIATION

本申请是为1999年7月3日至8日在佛蒙特州萨克斯顿河的佛蒙特学院举行的1999年FASEB“原核生物转录起始”夏季会议提供部分资金。这次会议由美国实验生物学学会联合会（FASEB）主办。将有10个主要的口头会议，每个会议平均包括三个30分钟的演讲和两个15分钟的演讲。将有两次海报会议，每次持续两天。讨论的主题包括：DNA依赖性RNA聚合酶的结构；用物理和化学方法研究转录过程中蛋白质-蛋白质和蛋白质- dna的相互作用；亚基结构、功能和催化；Sigma因子、反Sigma因子和核心相互作用；发起人（两届）；压制和沉默；延伸配合物的形成及稳定性；复杂的监管体系；还有信号转导。会议的重点是真细菌，但也会考虑古生菌和真核生物的比较是有趣的。会议的目的是将生物化学家、生物物理学家和遗传学家聚集在一起分享信息。该领域正在迅速发展，并在分子水平上提供了有关结构和机制的重要新信息。这是关于这个主题的第五次会议。前四次分别于1991年、1993年、1995年和1997年举行，参加人数非常多。

This application is for partial funding for the 1999 FASEB Summer Conference on "Transcription Initiation in Prokaryotes" to be held on July 3-8, 1999 at the Vermont Academy in Saxton's River, Vermont. The conference is held under the auspices of the Federation of American Societies for Experimental Biology (FASEB). There will be 10 major oral sessions, each including, on average, three 30 minute talks and two 15 minute talks per session. There will be two poster sessions, each lasting two days. The topics to be included for discussion are: structure of DNA- dependent RNA polymerases; physical and chemical approaches to study protein-protein and protein-DNA interactions in transcription; subunit structure, function, and catalysis; sigma factors, antisigmas, and core interactions; promoters (two sessions); repression and silencing; formation and stability of elongation complexes; complex regulatory systems; and signal transduction. The meeting focuses on eubacteria, but there will be consideration of both archaea and eukaryotes where comparison is interesting. The purpose of the meeting is to bring together biochemists, biophysicists and geneticists to share information. The field is progressing rapidly and providing important new information on structure and mechanisms at the molecular level. This is the fifth conference on the subject. The first four, held in 1991, 1993, 1995, and 1997, were very well attended.