LARGE-SCALE DISCOVERY AND GENETIC APPLICATIONS OF SNPS

单核苷酸多态(SNPs)是相当多的 注意它们作为遗传标记的潜力。《国家报》 卫生研究所(特别是国家人类基因组研究中心 研究所和国家癌症研究所)正在投入大量资金 发现SNPs并提供资源以使其能够使用 用于基因发现和其他目的。这些研究所正在鼓舞人心 SNP鉴定的技术进展--目标是尽可能多地 10万。此外，许多基于基因组的公司正在寻找SNPs 意图为它们申请专利。然而，许多问题仍然存在。 尚未解决；例如，寻找SNPs的最佳战略是什么， 所需数量(目前的估计范围为10倍，从30,000 到300,000)，以及SNPs的商业利用对 它们的用途。 这个研讨会的目的是让一小群 有人口遗传学、技术背景的科学家 发展和人类遗传学来讨论这些问题。此外, 与会者将对更广泛的政策问题感兴趣 由关于SNPs的公共和商业可获得性的辩论提出。 我们预计研讨会结束时，与会者将起草一份 需要立即关注的关键问题清单。

Single-nucleotide polymorphisms (SNPs) are the subject of considerable attention for their potential as genetic markers. The National Institutes of Health (in particular the National Human Genome Research Institute and the National Cancer Institute) are devoting major funds to the discovery of SNPs and to providing resources to enable their use in gene finding and for other purposes. The Institutes are encouraging technical developments for SNP identification-aiming for as many 100,000. In addition, many genome-based companies are hunting for SNPs with the intention of patenting them. However, many questions remain unresolved; for example, what are the best strategies for finding SNPs, the number needed (present estimates have a ten-fold range from 30,000 to 300,000) and what commercial exploitation of SNPs might mean for their use. The objective of this workshop is to bring together a small group of scientists with backgrounds in population genetics, technology development and human genetics to discuss these issues. In addition, there will be participants interested in the broader policy issues raised by the debate over public and commercial availability of SNPs. We expect that the workshop will finish with participants drawing up a list of key problems that need immediate attention.