Chronic Lyme Disease: New Strategies for Investigation, Diagnosis and Therapy

慢性莱姆病：调查、诊断和治疗的新策略

• 批准号: 7161650
• 负责人: JAN A WITKOWSKI
• 金额: $ 2.4万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7161650
• 关键词: Borrelia; Lyme disease; chronic disease /disorder; inflammation; meeting /conference /symposium; travel

DESCRIPTION (provided by applicant): Lyme Disease is a serious infection which can have a devastating impact on patients and diminish the quality of life of those who live in regions where the disease is endemic. Although there have been significant advances in the treatment of acute Lyme Disease, many questions remain about those patients who appear to be pathogen-free as determined by existing assays but continue to exhibit a variety of symptoms. In the apparent absence of the spirochete, these symptoms have been ascribed to many different causes, and this has delayed the development of effective therapies for these patients. It is essential that these patients should not feel marginalized and that we determine the underlying causes of their illness(es). To that end, we propose holding discussion meetings on three aspects of this problem, under the general title "Chronic Lyme Disease: New Strategies for Investigation, Diagnosis and Therapy". The first of these discussion meetings-"Strategies to Investigate Chronic Lyme Disease"-will be held at the Banbury Center of Cold Spring Harbor Laboratory, October 15-18, 2006. This meeting will provide a forum for the detailed critical review and analysis of this controversial topic, one of great import for those who have long-term disability following Lyme Disease. There will up to 36 invited participants, drawn from the leading laboratories throughout the world. Researchers from diverse technical and academic arenas be brought together to share their insights and discoveries. We will ensure representation of the various scientifically sustainable theories on the issue of chronic Lyme Disease. Topics in this first meeting will include, but will be not limited to, (1) critical review and discussion of data pertaining to: the presence or persistence of Borrelia burgdorferi in post-Lyme cases; (2) the possibility that there may be other unknown co-infections transmitted by the same tick-vector; and (3) the possibility that there are inflammatory triggered symptoms. Each session will be chaired by an expert in the topic and there will be not more than six speakers per session. The schedule will be arranged to ensure that there is time for discussion in each session, and a substantial part of the final session will be set apart for review of the key issues discussed and discussion of what future research is necessary. In addition, the Banbury Center venue provides ample time for continued interactions outside the Conference Room. The two subsequent meetings will follow the same organizational pattern. The topics under consideration for the meetings in 2007 and 2008 are "Diagnostics for Lyme disease" and" Therapy for Lyme disease and its Sequelae."

描述（由申请人提供）：莱姆病是一种严重的感染，可能对患者造成毁灭性影响，并降低居住在该疾病流行地区的人们的生活质量。 尽管急性莱姆病的治疗取得了重大进展，但对于那些根据现有检测确定似乎没有病原体但仍然表现出各种症状的患者，仍然存在许多问题。 在螺旋体明显缺失的情况下，这些症状被归因于许多不同的原因，这延迟了针对这些患者的有效疗法的开发。 重要的是，这些患者不应该感到被边缘化，并且我们要确定他们患病的根本原因。 为此，我们建议就该问题的三个方面举行讨论会议，总标题为“慢性莱姆病：调查、诊断和治疗的新策略”。 这些讨论会议中的第一次——“调查慢性莱姆病的策略”——将于 2006 年 10 月 15 日至 18 日在冷泉港实验室班伯里中心举行。这次会议将为对这一有争议的话题进行详细的批判性审查和分析提供一个论坛，这对于那些因莱姆病而长期残疾的人来说非常重要。 受邀参加者将多达 36 名，他们来自世界各地的领先实验室。 来自不同技术和学术领域的研究人员齐聚一堂，分享他们的见解和发现。 我们将确保关于慢性莱姆病问题的各种科学可持续理论的代表性。 第一次会议的主题包括但不限于：(1) 对以下数据进行严格审查和讨论：莱姆病后病例中伯氏疏螺旋体的存在或持续存在； (2) 可能存在由同一蜱虫传播的其他未知混合感染的可能性； (3)可能存在炎症引发症状。 每场会议将由该主题的专家主持，每场会议的发言者不超过六人。 日程安排将确保每场会议都有讨论时间，最后一场会议将留出相当一部分时间来回顾所讨论的关键问题并讨论未来研究的必要性。 此外，班伯里中心场地为会议室外的持续互动提供了充足的时间。 随后的两次会议将遵循相同的组织模式。 2007年和2008年会议审议的主题是“莱姆病的诊断”和“莱姆病及其后遗症的治疗”。