ANALYSIS OF LYMPHOPOIESIS IN ANEMIA

拟议研究的目标是获得培训和经验， 免疫学研究，同时进行旨在阐明 HA/HA中贫血和淋巴细胞扰动的相互作用 突变小鼠 对这种动物模型的评价将提供机会 一个更广泛的研究环境，可以用来专注于 淋巴细胞生成改变的问题 研究计划将允许开发 在新领域的专业知识：（1）标记研究，剖析细胞动力学 (2)使用特异性抗血清和流式细胞术分析亚群 （3）使用移植研究来检查任何关系 红细胞生成和淋巴细胞生成之间的关系，以及（4）评估 NK细胞在造血调节中的作用。 这些方面中的任何一个都可能 为今后的研究提供材料。 这些实验将在 在常规使用这些技术的实验室中， 监督在该领域地位稳固的个人。 表征 这种小鼠模型的研究可能为涉及正常 淋巴细胞生成及免疫与 造血系统

The goal of the proposed study is to obtain training and experience in immunological research while performing experiments designed to elucidate the interaction of anemia and lymphoid cell perturbations in the ha/ha mutant mouse. Evaluation of this animal model will provide the opportunity for a broadened research environment which can be used to focus on the question of altered lymphopoiesis. Research plan will allow development of expertise in new areas: (1) labeling studies to dissect cellular kinetics (2) use of specific antisera and flow cytometry to analyze subpopulations of cells (3) use of transplantation studies to examine any relationship between erythropoiesis and lymphopoiesis and (4) studies to evaluate the role of NK cells in hemopoietic regulation. Any one of these aspects could offer material for future studies. These experiments will be carried out in laboratories where the techniques are used routinely and under the supervision of well-established individuals in the field. Characterization of this mouse model may provide a resource for studies involving normal lymphopoiesis and the relationship between the immunologic and hematopoietic system.