CHILDHOOD PRECURSORS & CLINICAL OUTCOME IN SCHIZOPHRENIA

这项研究是一系列的发展调查， 精神分裂症的先兆及其与临床结局的关系 特征-症状、神经心理学特征和大脑 形态学 利用儿童时期的家庭电影， 精神分裂症患者的社会情感方面的发展将是 从婴儿期到青春期都有记录，并与 兄弟姐妹和非家族对照以及情感障碍患者 紊乱 童年各方面之间的关系 发展和患者作为成年人的特点将是 考察 这项研究还将探讨产前和产后的作用。 围产期因素和精神病家族史对精神病的预测作用 发展过程和临床结果。

The proposed research is a series of investigations of the developmental precursors of schizophrenia and their relation with clinical outcome characteristics -- symptoms, neuropsychological profiles and brain morphology. Using childhood home-movies, the neuromotor and socioemotional aspects of schizophrenic patients' development will be documented from infancy through adolescence, and contrasted with that of sibling and nonfamilial controls as well as patients with affective disorders. The relation between the various aspects of childhood development and the characteristics of patients as adults will be examined. The research will also explore the roles of prenatal and perinatal factors and family history of mental illness in predicting developmental course and clinical outcome.