REPRODUCTIVE FAILURE: MENTAL HEALTH EFFECTS IN WOMEN

请求获得ADAMHA颁发的I级研究科学家发展奖 目的研究生育失败对女性心理健康的影响。宽泛 建议在三个一般领域进行培训--性类固醇对 脑与行为；老年性痴呆患者临床表现的研究 各种内分泌紊乱，包括青春期衰竭， 不孕症和雌激素缺乏症的方法学 跨学科研究(设计、评估方法和数据分析) 生殖障碍妇女的行为表现。这个 首先，这些领域将通过精神内分泌学的工作来涵盖 纽约州立精神病学研究所的研究小组，由Dr。 书名/作者Heino F.L.Meyer-bahlburg.它将包括 参与两项研究--一项关于长期精神健康影响的研究 产前接触己烯雌酚(DES)和一项关于性唤醒和 同性恋和异性恋女性的类固醇激素水平。第二 主要领域将包括性问题专家委员会的培训 激素、临床内分泌学和不孕症。第三个主要区域 包括研究设计、测量开发和 由方法论专家进行统计。初步研究项目是 将重点介绍青春期延迟对心理健康的影响， 患有特纳综合征的成年妇女的生长迟缓和不孕。 来自这项研究以及上述培训的信息 将用于第二个关于心理健康的研究项目 不同育龄妇女对不孕症的影响 失败(包括特纳综合征、睾丸女性化、暴露于 产前己烯雌酚与解剖学不孕症 生殖道异常)。这些研究将评估 首次系统地研究了特定的心理健康效应 生殖衰竭的证候，将有助于澄清一些具体的 女性精神障碍的病因学机制。结果是 将填补当前临床知识的空白，并将使其成为可能 制定预防和治疗心理健康的临床策略 妇女医疗保健系统中的问题。

Requested is a Research Scientist Development Award, Level I, from ADAMHA to study mental health effects of reproductive failure in women. Broad training is proposed in three general areas -- effects of sex steroids on brain and behavior; the study of clinical manifestations of patients with a variety of endocrinological disorders, including pubertal failure, infertility and estrogen deficiency; and the methodology of interdisciplinary research (design, assessment methods, and data analysis) on behavioral manifestations of women with reproductive disorders. The first of these areas will be covered by working in the Psychoendocrinology Research Unit at the New York State Psychiatric Institute, directd by Drs. Anke A. Ehrhardt and Heino F.L. Meyer-Bahlburg. It will include participation in two studies -- one on long-term mental health effects of prenatal diethylstilbestrol (DES) exposure and one on sexual arousal and steroid hormone levels in homosexual and heterosexual women. The second main area will involve training from a committee of experts on sex hormones, clinical endocrinology, and infertility. The third main area consists of training in research design, measure development, and statistics by experts in methodology. A preliminary research project is described which will focus on mental health effects of delayed puberty, growth retardation and infertility in adult women with Turner syndrome. Information from this study as well as from the training described above will be used in a second research project forcusing on mental health effects of infertility in different groups of women with reproductive failure (including Turner syndrome, testicular feminization, exposure to prenatal diethylstilbestrol, and infertility due to anatomical abnormalities of the reproductive tract). These studies will assess systematically for the first time the mental health effects of specific syndromes of reproductive failure and will help to clarify some specific mechanisms in the etiology of p]sychiatric disorders in women. The results will fill a gap in current clinical knowledge and will make it possible to devise clinical strategies in the prevention and treatment of mental health problems in the health care system for women.