NEW BIOPOLYMERS DERIVED FROM ALPHA-L-AMINO ACIDS

候选人的长期目标是建立一个有 在生物材料开发、多肽化学和 聚合物化学。候选人的工作重点是设计， 新型分子结构的合成与表征。在这些地区 生物材料研究和聚合物化学的候选人正在开发 合成聚氨基主链修饰的新方法 酸)。他的合成方法是基于α-L的聚合- 氨基酸通过它们的侧链，导致非- 酰胺与多(氨基酸)主链结合。这样的主干修改 “拟多(氨基酸)作为医学生物材料具有潜在的用途。 可植入设备、可注射药物载体和 生物相容涂层或膜。其物理化学性质 以及伪聚(氨基)的免疫学和毒理学性质 酸)将被表征。在多肽化学领域， 候选人正在探索氨基甲酸酯连接的可能用途，如 模拟传统多肽键的假肽。作为一名模特 系统，合成了一种新的环伪四肽，它含有 两个氨基甲酸酯键作为其环结构的一部分。

The candidate's long-term goal are to establish a laboratory with recognized expertise in biomaterials development, peptide chemistry and polymer chemistry. The candidate's work id focused on the design, synthesis and characterization of new molecular structures. In the areas of biomaterials research and polymer chemistry, the candidate is developing new methods for the modification of the backbone of synthetic poly(amino acids). His synthetic approach is based on the polymerization of alpha-L- amino acids via their side chains, resulting in the incorporation of non- amide bonds into the poly(amino acid) backbone. Such backbone-modified "pseudo-poly(amino acids) have potential uses as biomaterials for medical applications e.g. implantable devices, injectable drug carriers, and biocompatible coatings or membranes. The physical and chemical properties and the immunological and toxicological properties of pseudo-poly(amino acids) will be characterized. In the area of peptide chemistry, the candidate is exploring the possible use of urethane linkages as pseudopeptide mimetics of the conventional peptide bond. As a model system, a new cyclic pseudotetrapeptide has ben synthesized that contains two urethane bonds as part of its ring structure.