DYNAMICS OF RESPIRATORY INSTABILITY IN HUMANS IN SLEEP

申请研究职业发展奖的目的是 允许主要研究者（PI） 他的一部分时间用于研究睡眠对对照组的影响， 呼吸。 在此提议项目的任期内，PI将 联合收割机数学建模和参数估计方法学与 在人类身上进行实验，以更好地了解 导致呼吸变异和反复呼吸暂停的机制， 睡吧 RCDA将腾出足够的时间让他进行 建议的研究，以及获得坚实的基础，在临床和 通过阅读睡眠的神经生理学方面， 与该领域的专家合作，并参加座谈会。 的 通过这种机会获得的经验和培训将是 对他目前和未来的发展是非常宝贵的， 睡眠生理学研究者，尤其是 呼吸控制 同时，PI将能够探索 适用性的新方法来自非线性动力学，混沌 理论和神经网络。 大学里有几个 这些新领域以及神经科学的专家提供了一个 PI学术成长的理想环境。 纳入两 临床同事，一个在肺部医学，另一个在睡眠 疾病，因为本项目的合作研究者将显著改善 私家侦探对睡眠的病理生理学方面的理解 在拟议的项目中，实验将在健康的 受试者和睡眠呼吸暂停综合征患者， 化学反应性、动脉血气敏感性的重要性 紧张局势的解释性变化（植物增益），呼吸相位转换， 睡眠状态变化和上气道力学在介导睡眠相关 呼吸障碍 简单的非侵入性手术， 设计的计算算法将允许跟踪 化学反应，植物增益和睡眠期间的动脉血气。 建模的应用还允许估计时间进程， “清醒刺激”。 分析了在时间上的关系 这些因素和上呼吸道阻力的变化将被用于扩展 睡眠状态和呼吸之间相互作用的现有模型 控制

The purpose of this application for a Research Career Development Award is to permit the Principal Investigator (PI) to devote a substantially greater portion of his time for research into the effects of sleep on the control of breathing. During the tenure of this proposes project, the PI will combine mathematical modeling and parameter estimation methodology with experiments on humans to obtain a better understanding of the dynamic mechanisms that lead to respiratory variability and recurrent apnea during sleep. The RCDA will free up sufficient time for him to conduct the proposed studies, as well as to obtain a firm grounding in the clinical and neurophysiological aspects of sleep through reading, increased interactions with experts in the field, and participation in colloquiums. The experience and training obtained through such an opportunity would be invaluable for his current and future development as in independent investigator in sleep physiology, particularly as it pertains to respiratory control. At the same time, the PI will be able to explore the applicability of new approaches derived from nonlinear dynamics, chaos theory and neural networks. The presence within the University of several experts in these new areas, as well as in the neurosciences, provides an ideal environment for the academic growth of the PI. The inclusion of two clinical colleagues, one in pulmonary medicine and the other in sleep disorders, as Co-Investigators in this project will significantly improve the PI's appreciation of the pathophysiological aspects of sleep. In the proposed project, experiments will be performed on both healthy subjects and patients with sleep apnea syndrome to determine the relative importance of chemoresponsiveness, sensitivity of arterial blood gas tensions to ventilatory changes (plant gain), respiratory phase-switching, sleep state changes and upper airway mechanics in mediating sleep-related breathing disorders. Simple noninvasive procedures combined with specially designed computational algorithms will be permit the tracking of chemoresponsiveness, plant gain, and arterial blood gases during sleep. Application of modeling also allows the estimation of the time-course for the 'wakefulness stimulus'. Analysis of the temporal relationships between these factors and changes in upper airway resistance will be used to extend an existing model of the interaction between sleep state and respiratory control.