PULMONARY MASS AND HEAT TRANSPORT

肺质热五题 扩散性（气体）和扩散性差（气溶胶）的输送 污染物将通过硬件实验进行检查， 应用数学分析 总体目标是解决 肺转运现象的各个方面， 由生理和临床背景，并植根于基本流体 力学 具体而言，这五个专题是： I. 容积循环振荡的实验研究 刚性气道分叉模型中的流动：流速 将使用双分量激光多普勒进行测量 风速计 这项技术的应用将为 关于这一复杂流程的信息将在II中使用， 解释它对交通的意义。 同时的压力 将进行测量以表征阻抗 详细的流动现象的信息。 二. 体积循环振荡流的理论研究 并在弯曲的管道中运输。 轴向曲率的影响， 其引起横向流动运动， 检查速度、压力和浓度 领域的 该系统的整体有效扩散率Deff将 被确定并直接与频率，振幅， 分子扩散率和轴向曲率。 三. 体积循环振荡流的理论研究 以及在柔性通道中的质量传输。 数学分析 在这种流动条件下的速度场和压力场将是 为了确定侧壁如何运动 影响详细的速度分量，随后， 分散和流动特性。 直接依赖 将寻求对墙合规性的Deff。 四. 容积循环振荡的实验研究 在一个灵活的渠道。 通过修改我们之前的频道 实验中，我们将研究染料条纹的变形， 分析轴流。 流媒体既是衡量 扩散性差的污染物的运输和 影响Deff的非定常速度。 诉 液滴在液膜上的铺展和输运。 了理论 分析液滴（气溶胶）如何在薄膜上扩散 液体膜（肺的衬里）表面张力的影响。 的 液滴和液膜中的诱导流场将强烈影响 将所含溶质（药物、毒素）输送到气道 墙

Five related projects concerning pulmonary mass and heat transport for diffusible (gases) and poorly diffusible (aerosols) contaminants will be examined by hardware experiments and applied mathematical analysis. The overall aim is to address aspects of pulmonary transport phenomena which are motivated by physiological and clinical contexts and rooted in basic fluid mechanics. Specifically the five topics are: I. An experimental investigation of volume-cycled oscillating flow in a rigid, airway bifurcation model: flow velocity measurements will be made using a two-component laser doppler anemometor. Application of this technology will provide new information on this complicated flow that will be used in II to interpret its significance for transport. Simultaneous pressure measurements will be made to characterize impedance information with detailed flow phenomena. II. A theoretical investigation of volume cycled oscillatory flow and transport in a curved tube. The effects of axial curvature, which induce lateral streaming motions will be isolated and examined with respect to velocity, pressure and concentration fields. The overall effective diffusivity, Deff, of this system will be determined and directly related to frequency, amplitude, molecular diffusivity and axial curvature. III. A theoretical investigation of volume-cycled oscillatory flow and mass transport in a flexible channel. A mathematical analysis of velocity and pressure fields for this flow condition will be carried out in order to determine how the lateral wall motions influence the detailed velocity components and, subsequently, the dispersive and streaming characteristics. The direct dependence of Deff on wall compliance will be sought. IV. An experimental investigation of volume-cycled oscillatory flow in a flexible channel. By modifying our previous channel experiments, we will study the deformation of dye streaks to analyze axial streaming. Streaming is both a measure of transport for poorly diffusible contaminants and a signature of the unsteady velocities which influence Deff. V. Droplet spreading and transport on liquid film. A theoretical analysis of how a liquid droplet (an aerosol) spreads on a thin liquid film (lung's lining) from surface tension effects. The induced flow fields in the droplet and film will strongly influence the transport of contained solutes (drugs, toxins) into the airway wall.