PHYSIOLOGICAL PSYCHOLOGY OF MOTIVATED BEHAVIOR

这一建议涉及对食物的两种影响的分析 刺激--餐后饱腹感和奖赏。 分析包括 确定足够的食物刺激及其特定的前吸收 和/或吸收后作用部位。 那么这些外围刺激 用于识别由食物刺激激活的外周机制， 被食物刺激改变的中枢机制 对餐后饱腹感的分析使我们认识到， 许多饱腹感信号来自食物刺激物对前吸收的作用， 从嘴到小肠末端的肠道表面。 这表明，吸收前饱腹感机制可能会改变， 人类和动物暴食和肥胖综合征。 我们正在调查这个 在遗传性肥胖（obob）小鼠中，在腹内侧 下丘脑损伤大鼠和正常大鼠在摄食过多时的摄食量。 胆囊收缩素（CCK）是一种来自小肠的饱腹感信号 因此是一种潜在的肥胖症治疗剂。 我建议研究其 长期治疗OBOB小鼠的有效性。 腹部迷走神经切断术也被提议作为治疗严重的 肥胖 我建议研究它对吸收前饱腹感的影响， 对obob小鼠摄食量和体重的影响，以及 它在口渴时会产生许多缺陷。 对食物奖赏的分析将为研究食物奖赏提供基础知识。 生理机制，并可能提供新的实验 人类进食障碍的治疗方法和潜在疗法。

This proposal is concerned with an analysis of two effects of food stimuli-- postprandial satiety and reward. The analysis consists of determining the adequate food stimuli and their specific preabsorptive and/or postabsorptive sites of action. Then these peripheral stimuli are used to identify the peripheral mechanisms activated by food stimuli and the central mechanisms that are altered by food stimuli. The analysis of postprandial satiety has led to the realization that a number of satiety signals arise from food stimuli acting preabsorptively on the surface of the gut from the mouth to the end of the small intestine. This has suggested that preabsorptive satiety mechanisms may be altered in human and animal syndromes of hyperphagia and obesity. We investigate this possibility in the genetically obese (obob) mouse, in the ventromedial hypothalamic lesioned rat and in the normal rat during noctural hyperphagia. Cholecystokinin (CCK) is a putative satiety signal from the small intestine and thus a potential therapeutic agent for obesity. I propose to study its effectiveness during chronic treatment of obob mice. Abdominal vagotomy has also been proposed as a treatment for severe obesity. I propose to investigate its effect on preabsorptive satiety, its effect on food intake and body weight in obob mice, and the mechanism(s) by which it produces numerous deficits in thirst. The analysis of food reward will provide fundamental knowledge about its physiological mechanisms and it is likely to provide new experimental approaches to, and potential therapies for, human feeding disorders.