PULMONARY MASS AND HEAT TRANSPORT

与肺肿块和热相关的五个项目 可扩散(气体)和难扩散(气溶胶)的传输 污染物将通过硬件实验和 应用数学分析。总体目标是解决 激发肺转运现象的几个方面 根据生理和临床情况，植根于基础液体 机械师。具体来说，这五个主题是： I.体积循环振荡的实验研究 刚性气道分叉模型中的流动：流速 测量将使用双分量激光多谱勒进行 风速计。这项技术的应用将提供新的 有关这一复杂流动的信息，将在II至 解读它对交通运输的意义。同时加压 将进行测量以表征阻抗 具有详细流动现象的信息。 II.体积循环振荡流的理论研究 并在弯曲的管子中运输。轴曲率的影响， 引起侧向流动运动的物质将被隔离 根据速度、压力和浓度进行检查 菲尔兹。该系统的总体有效扩散系数Deff将 被确定并直接与频率、幅度、 分子扩散系数和轴向曲率。 体积循环振荡流的理论研究 并在灵活的通道中进行大规模传输。一种数学分析 此流动条件下的速度场和压力场的 以确定侧壁如何运动 影响详细的速度分量，并随后影响 分散性和流行性。直接依存性 将寻求关于墙壁合规性的Deff。 IV.体积循环振荡的实验研究 在灵活的渠道中流动。通过修改我们之前的频道 实验中，我们将研究染料条纹的变形 分析轴向流动。流媒体既是一种衡量标准， 扩散性差的污染物的传输和签名 影响Deff的非定常速度。 液滴在液膜上的扩散和传输。一个理论上的 液滴(气溶胶)如何在薄片上传播的分析 来自表面张力效应的液体薄膜(肺的衬里)。这个 液滴和液膜中的诱导流场将强烈地影响 将含有的溶质(药物、毒素)输送到呼吸道 墙。

Five related projects concerning pulmonary mass and heat transport for diffusible (gases) and poorly diffusible (aerosols) contaminants will be examined by hardware experiments and applied mathematical analysis. The overall aim is to address aspects of pulmonary transport phenomena which are motivated by physiological and clinical contexts and rooted in basic fluid mechanics. Specifically the five topics are: I. An experimental investigation of volume-cycled oscillating flow in a rigid, airway bifurcation model: flow velocity measurements will be made using a two-component laser doppler anemometor. Application of this technology will provide new information on this complicated flow that will be used in II to interpret its significance for transport. Simultaneous pressure measurements will be made to characterize impedance information with detailed flow phenomena. II. A theoretical investigation of volume cycled oscillatory flow and transport in a curved tube. The effects of axial curvature, which induce lateral streaming motions will be isolated and examined with respect to velocity, pressure and concentration fields. The overall effective diffusivity, Deff, of this system will be determined and directly related to frequency, amplitude, molecular diffusivity and axial curvature. III. A theoretical investigation of volume-cycled oscillatory flow and mass transport in a flexible channel. A mathematical analysis of velocity and pressure fields for this flow condition will be carried out in order to determine how the lateral wall motions influence the detailed velocity components and, subsequently, the dispersive and streaming characteristics. The direct dependence of Deff on wall compliance will be sought. IV. An experimental investigation of volume-cycled oscillatory flow in a flexible channel. By modifying our previous channel experiments, we will study the deformation of dye streaks to analyze axial streaming. Streaming is both a measure of transport for poorly diffusible contaminants and a signature of the unsteady velocities which influence Deff. V. Droplet spreading and transport on liquid film. A theoretical analysis of how a liquid droplet (an aerosol) spreads on a thin liquid film (lung's lining) from surface tension effects. The induced flow fields in the droplet and film will strongly influence the transport of contained solutes (drugs, toxins) into the airway wall.