PERIPHERAL MECHANISMS OF ESOPHAGEAL PERISTALSIS

这项建议的总体目标是详细研究 肌腱蠕动行为的内壁机制 食道的平滑肌肉部分。具体来说，这将是 包括使用电生理细胞内记录 检查壁间突触传递的技术 食道内肌间神经丛的神经 神经肌肉部位。这些研究的结果应该会提供一个 增加对壁间神经肌肉的了解 参与食道蠕动的机制并导致更好的 对本病的病理生理学认识及处理 食道疾病，如失弛缓症和弥漫性食道痉挛。 克里斯特博士目前是一名医学讲师 贝丝以色列医院和哈佛大学的胃肠病科 医学院。在拉杰·K·戈亚尔博士的赞助下，他 一直是个人国家研究服务的获得者 获奖(1983-1985)和临床研究人员奖(1985-1988) 探讨食道蠕动的发生机制。 候选人在这段时间内的研究结果是 六份原创出版物(见附录)。 通过临床研究人员奖博士提供的资金。 克里斯特最近在R.A.博士的实验室工作。 North和A.Surprenant在麻省理工学院 技术。这段经历让克里斯特博士成为了 具备电生理技术方面的知识 目前的提议。 赞助商拉杰·K·戈亚尔博士是哈佛大学的医学教授 哈佛医学院和贝斯大学消化内科主任 以色列医院，是该领域公认的领导者 胃肠动力。戈亚尔博士的赞助，以及 贝丝以色列医院和哈佛大学的调查人员 医学院，应该提供一个良好的环境 候选人的学习和全面发展成为一名 独立调查员。

The overall objective of this proposal is to examine in detail the intramural mechanisms responsible for peristaltic behavior in the smooth muscle portion of the esophagus. Specifically, this will involve the use of electrophysiological intracellular recording techniques to examine synaptic transmission between intramural nerves of the myenteric plexus in the esophagus as well as at the neuromuscular site. The results of these studies should provide an increased understanding of the intramural neuromuscular mechanisms involved in esophageal peristalsis and lead to a better understanding of the pathophysiology and management of such esophageal disorders as achalasia and diffuse esophageal spasm. Dr. Crist is presently an Instructor in Medicine in the Gastroenterology Division of the Beth Israel Hospital and Harvard Medical School. Under the sponsorship of Dr. Raj K. Goyal, he has been the recipient of an Individual National Research Service Award (1983-1985) and a Clinical Investigator Award (1985-1988) to study the mechanisms responsible for esophageal peristalsis. Studies by the candidate during this time period have resulted in six original publications (see Appendix). Through funding provided by the Clinical Investigator Award Dr. Crist has most recently worked in the laboratory of Drs. R.A. North and A. Surprenant at Massachusetts Institute of Technology. This experience has allowed Dr. Crist to become knowledgeable in the electrophysiological techniques to be used in the present proposal. The sponsor, Dr. Raj K. Goyal, is Professor of Medicine at Harvard Medical School and Chief of Gastroenterology at Beth Israel Hospital and is an acknowledged leader in the area of gastrointestinal motility. Dr. Goyal's sponsorship, as well as the surrounding investigators at Beth Israel Hospital and Harvard Medical School, should provide an excellent environment for the candidate's studies and overall development toward becoming an independent investigator.