Intelligently linking nanoscience to neuroscience with glycan biology

本项目旨在全面描述炎症神经元、星形胶质细胞、小胶质细胞和少突胶质细胞中独特的细胞表面聚糖表达。该项目将使用聚糖分析数据来设计具有优越神经成像质量的发光纳米颗粒，用于中枢神经系统中细胞类型特异性的体内靶向和药物递送。该项目的成果有望提高我们对神经生物学细胞表面的基本理解。

This project aims to provide a comprehensive description of the unique cell-surface glycan expression on inflamed neurons, astrocytes, microglia and oligodendrocytes. This project will use glycan profiling data to engineer luminescent nanoparticles with superior neuroimaging qualities for cell type-specific in vivo targeting and drug delivery in the central nervous system. The project outcomes are expected to improve our fundamental understanding of neurobiological cell-surfaces.