GERIATRIC DENTISTRY FOR THE ALZHEIMER'S PATIENT

1.阐明28 k维生素D诱导的 钙结合蛋白（CaBP）及其在阿尔茨海默病中的作用 疾病 尸检人脑组织从减少病人 将分析阿尔茨海默病患者的钙分布 和专注 这方面研究的目标是 为了确定CaBP在这一发病机制中的作用， 神经退行性疾病 这项研究将决定 神经元CaBP的变化是否会使神经元对 间歇性钙波动，因此容易积累 生理上无法忍受的钙量，所有这些 会导致细胞内钙离子不受控制的升高 导致蛋白质变性和最终的细胞死亡; 2.确定哪些人类染色体包含该基因 编码CaBP，并将CaBP基因定位在 那个染色体 3.阐明当前临床技术的可能适应性 新技术的应用， 老年痴呆症患者，以提供优质，低成本的牙科 在诊所或机构环境中照顾他们。 一 最近开发的光固化技术， 口腔修复服务将作为评估的基础。

1. elucidate the relationship of the 28k Vitamin D-induced Calcium Binding Protein (CaBP) to, and its role in Alzheimer's disease. Autopsied human brain tissue from decreased patients with Alzheimer's disease will be analyzed for calcium distribution and concentration. The goal of this aspect of the research will be to ascertain the role of CaBP in the pathogenesis of this neurodengenerative disorder. The research will determine whether changes in neuronal CaBP renders neurons susceptible to intermittent calcium fluctuations and thus prone to accumulating physiologically intolerable quantities of calcium, all of which could result in an uncontrolled elevation of intracellular calcium leading to protein denaturation and eventual cell death; 2. establish which human chromosomes contains the gene coding for CaBP and to map the location of the CaBP gene on that chromosome. 3. elucidate possible adaptation of present clinical techniques and applications of new technologies in the treatment of Alzheimers' patients in order to provide quality, low-cost dental care to them in either a clinic or institutional setting. A recently-developed light-curing technique for removable prosthodontic services will serve as the basis for this evaluation.