MINORITY SCHOOL FACULTY DEVELOPMENT AWARD

刺激突触前外周多巴胺受体(DA2)产生 交感神经抑制导致低血压。突触后外周 多巴胺受体(DA1)激活亚服务器的血管扩张和利尿作用。 外周高特异性激动剂的设计与合成 多巴胺受体已经进化成一种控制 高血压。N，N-二正丙基多巴胺的外周作用 多巴胺受体导致血压和心脏减少 速度刺激了类似化合物的合成。潜力 这些取代(芳烷基)苯乙胺的临床应用 当前感兴趣的话题。 这项研究项目建议(A)合成和表征一系列 苯乙胺的N-芳烷基衍生物和相关化合物，(B) 评估这些化合物对外周多巴胺的有效性 使用局部血流测量的受体(脉冲多普勒 流量计)和(C)进一步表征外周血中的多巴胺 使用化学探针(即重金属)的受体。综合方案 发展将是这项调查的主要主题。区域血液 流量测量将在清醒和麻醉的动物身上进行。 外周多巴胺受体活性。化学探测法 接收器还将使用区域血流测量技术。这个 拟议的研究具有重要意义，因为它可能提供一系列新的 抗高血压药物和有关外周血细胞的更多信息 多巴胺受体。

Stimulation of presynaptic peripheral dopamine receptors (DA2) produces sympathoinhibition resulting in hypotension. Postsynaptic peripheral dopamine receptor (DA1) activation subserver's vasodilation and diuresis. The design and synthesis of highly specific agonists for peripheral dopamine receptors have evolved into a new approach for the control of hypertension. The action of N, N-di-n-propyldopamine on peripheral dopamine receptors resulting in reduced blood pressure and reduced heart rate has stimulated the synthesis of similar compounds. The potential clinical application of these substituted (aralkyl) phenethylamines is a topic of current interest. This research project proposes to (a) synthesize and characterize a series of N-aralkyl derivatives of phenethylamine and related compounds, (b) evaluate the effectiveness of these compounds on peripheral dopamine receptors utilizing regional blood flow measurements (pulsed Doppler flowmeter) in rats and (c) further characterize the peripheral dopamine receptors using chemical probes (i.e., heavy metals). Synthetic scheme development will be a major thrust of this investigation. Regional blood flow measurements will be performed in conscious and anesthetized animals for peripheral dopamine receptor activity. Chemical probing of the receptors will also use the regional blood flow measurement technique. The proposed research is significant because it may provide new series of antihypertensive agents and additional information about peripheral dopamine receptors.