LATENT MEMBRANE PROTEIN-1 OF EBV IN THE RECOGNITION OF INFECTED B LYMPHOCYTES

爱泼斯坦-巴尔病毒是疱疹病毒家族的成员， 感染大多数人类，并可能无限期地留在人体内， 通常以潜伏感染的形式出现。EB病毒可以改变B- 并使其永生。据说EB病毒是 包括恶性肿瘤在内的许多疾病的原因 免疫功能受损的病人。 T淋巴细胞在控制人类免疫缺陷病毒感染中起主要作用。 转化的B细胞群体。一些潜伏的病毒蛋白 已知在识别受感染的B-病毒方面很重要 杀伤T淋巴细胞所致的淋巴细胞。 该项目旨在研究T细胞溶细胞性克隆，即 识别潜伏膜蛋白-1(LMP-1)的部分 主要由I类分子呈递给T细胞受体 组织相容性复合分子(MHC)。大约100 针对EB病毒的细胞溶解T细胞克隆已经产生。 感染了B细胞，并部分鉴定了。

Epstein-Barr virus (EBV), a member of the herpes virus family, infects most humans and may remain in the body indefinitely, generally in the form of a latent infection. EBV can transform B- lymphocytes and cause their immortalization. EBV is said to be the cause of a number of diseases including malignancies in the immunocompromised patients. T-lymphocytes are of primary importance in controlling the transformed B-cell population. Some of the latent viral proteins are known to be important in the recognition of infected B- lymphocytes by killer T-lymphocytes. This project is designed to study T-cell cytolytic clones, that recognize portions of the Latent Membrane Protein-1 (LMP-1), which are presented to the T-cell receptor by Class I major histocompatibility complex molecules (MHC). Approximately 100 cytolytic T-cell clones have already been generated against EBV- infected B-cells and partially characterized.