Uncovering vertebrate lifespan biodiversity with whole genome sequencing

本项目旨在利用全基因组测序和比较系统基因组学相结合的新方法，整合模型系统中寿命进化遗传机制的现有数据，揭示脊椎动物寿命进化的共同基因组特征。预期的结果包括对寿命演变的看法，这是澳大利亚和其他发达国家对主要健康问题感兴趣的主题。这将带来巨大的好处，比如对老龄化研究的长期影响，以及可能的商业应用。它还将提高澳大利亚在发展中的生物信息学领域的知名度和竞争力。

This project aims to integrate existing data on the genetic mechanisms of lifespan evolution in model systems with a novel combination of whole genome sequencing and comparative phylogenomics to reveal the common genomic signatures of lifespan evolution in vertebrates. Expected outcomes include a perspective on the evolution of lifespan, a topic of major health interest for Australia and the rest of the developed world. This will provide significant benefits, such as long-term implications for aging research, with possible business applications. It will also increase Australia’s visibility and competitiveness in the developing field of bioinformatics.