AUTOLOGOUS MARROW TRANSPLANTATION

一个实验室和临床研究计划，旨在 了解自体骨髓移植的过程 (AMI)并提出了改进方法。 实验室项目 将致力于更好地理解 造血以设计改善骨髓的方法 AMI后功能 其他实验室项目将针对 通过溶解从骨髓中去除恶性细胞群， 单克隆抗体和补体或通过阳性选择 造血祖细胞 体外检测方法 还将评价清除后残留的恶性细胞。 临床研究将涉及急性淋巴细胞白血病患者 白血病，急性非淋巴细胞白血病，恶性淋巴瘤，和 多发性骨髓瘤，并将致力于定义的作用， AMT在这些疾病的治疗以及探索途径 为了使用新的制备方案改善当前的结果， 体外净化和移植后生物反应调节剂。 核心计划，开展拟议的研究至关重要 项目，包括生物统计和信息服务， 病理学、门诊护理和长期随访，以及 局

A program of laboratory and clinical research directed at understanding the process of autologous marrow transplantation (AMI) and improving its results is proposed. Laboratory projects will be directed toward better understanding of the mechanisms of hematopoiesis in order to design methods of improving marrow function after AMI. Other laboratory projects will be directed at removing populations of malignant cells from marrow by lysis with monoclonal antibodies and complement or by positively selecting for hematopoietic progenitor cells. In vitro methods of detecting residual malignant cells after purging will also be evaluated. Clinical research will involve patients with acute lymphoblastic leukemia, acute nonlymphoblastic leukemia, malignant lymphoma, and multiple myeloma and will be directed towards defining the role of AMT in the treatment of these diseases as well as exploring ways to improve current results using new preparative regimens, better in vitro purging, and post-transplant biologic response modifiers. Core programs, essential in carrying out the proposed research projects, include Biostatistics and Information Services, Pathology, Outpatient Care and Long-term Follow-up, and Administration.