PHOTODYNAMIC THERAPY: BASIC SCIENCE STUDIES

本建议的总体目标是制定一个更好的 了解基本的作用机制， 光动力疗法（PDT）。 该计划是一个集成的 韦恩州立亨利福特医院的研究活动 奥克兰大学和奥克兰大学的直接延伸 在PDT领域正在进行的其他研究合作。 的 该项目由两个核心和四个单独的提案组成。 的 核心是支持总体行政职能， 为所有四个项目提供生物统计支持。 项目1建议调查 PDT在宠物动物原发性肿瘤中的有效性。 项目 2计划研究PDT与 另一种新的治疗方式，热疗， 至少有一种生理反应机制， PDT。 正常组织对PDT的反应，特别是大脑，将是 在项目3中学习。 最后，项目4建议比较PDT 从传统的照明到 化学发光 最终，这些研究将提供一个 更好地了解参与的基本机制， PDT。

The overall objective of this proposal is to develop a better understanding of the basic mechanisms of action of Photodynamic Therapy (PDT). The program is an integration of research activities at Henry Ford Hospital, Wayne State University and Oakland University and a direct extension of other ongoing research collaborations in the area of PDT. The project consists of two cores and four separate proposals. The cores are to support overall administrative functions and for biostatistical support of all four projects. Project 1 proposes to investigate parameters for the effectiveness of PDT in primary tumors in pet animals. Project 2 plans to investigate the possibility of combining PDT with another new treatment modality, hyperthermia, which has at least one physiological response mechanism in common with PDT. Normal tissue response to PDT, in particular brain, will be studied in Project 3. Finally, Project 4 proposes to compare PDT with conventional illumination to illumination by chemiluminescence. Ultimately, these studies will provide a better understanding of the underlying mechanisms involved in PDT.