OSTEOPOROSIS--PREVENTION AND TREATMENT

这项提议的长期目标是开发更好的方法来 防治骨质疏松症。二十六大学 代表九个学科的加州调查人员 制定了六个科学项目(SP)和三个可行性研究 (FS)来实现这一点。小型实验室、临床、统计和 已经成立了行政核心来支持这些科学 项目和可行性研究节省了相当多的美元。 我们的中心主题是骨质疏松症和骨折预防。SP#1 探讨雌激素对小鼠卵巢功能的影响 绝经后妇女对维生素D代谢和肠道的影响 钙的吸收。它应该回答这个重要的问题，是吗？ 雌激素促进1，25-二羟基维生素D的产生及其游离 血清中的浓度？SP#2评估内源性酸 绝经后妇女的生育能力会导致负面影响 钙平衡并将决定HCO3给药是否会 纠正这一反常现象。SP#3评估了一种新的方法 分析椎骨的QCT数据可以提供关键 结构信息将允许准确预测 骨折。SP#4测试准确度、精密度和 一种新开发的高速(1-2分钟)双通道的适用性 革命性设计的光子吸收扫描仪用于评估骨骼 多个地点的矿物质含量。这样的仪器具有 解决目前筛查中的主要问题的潜力， 扫描所需的时间。SP#6测试的是 相干治疗计划，使用合成甲状旁腺 激素和降钙素，以增加骨矿含量 女性确诊脊柱骨质疏松症患者。两个FS 研究基本的骨细胞生物学，人们将评估 一种人类药物诱导的雌激素缺乏性骨丢失模型 适用于检测具有预防作用的新药。

The long range goal of this proposal is to develop better ways to prevent and treat osteoporosis. Twenty-six University of California investigators representing nine disciplines have developed six Scientific Projects (SP) and three Feasibility Studies (FS) to accomplish this. Small laboratory, clinical, statistical and administrative cores have been formed to support these Scientific Projects and Feasibility Studies at a considerable dollar savings. Our central theme is osteoporosis and fracture prevention. SP #1 investigates the effect of estrogen administration to postmenopausal women on vitamin D metabolism and intestinal calcium absorption. It should answer the important question, does estrogen increase 1,25-dihydroxyvitamin D production and its free concentration in serum? SP #2 assesses whether endogenous acid production in postmenopausal women contributes to negative calcium balance and will determine if HCO3 administration will correct this abnormality. SP #3 evaluates a new approach to analyzing QCT data of vertebra which could provide key structural information that would permit accurate prediction of fracture. SP #4 tests the accuracy, precision and the applicability of a newly developed high speed (1-2 min) dual photon absorption scanner of revolutionary design to assess bone mineral content at multiple sites. Such an instrument has the potential of solving the major current problem in screening, that of the time required for scanning. SP #6 tests the ability of a coherence treatment program, using synthetic parathyroid hormone and calcitonin, to increase bone mineral content in women patients with established spinal osteoporosis. Two FS' investigate basic bone cell biology and one will evaluate whether a human drug induced model of estrogen deficiency bone loss is suitable for testing new drugs with prophylactic potential.