ROLE OF CNS ADAPTIVE MECHANISMS IN OROFACIAL SENSATION

该项目的目的是：（一）确定和描述 动态中枢神经系统适应机制， 控制大脑皮层对躯体刺激的反应， 正常受试者，以及（ii）确定其对 操作和已知与 一组研究人员发现， 在躯体感觉神经生理学方面具有丰富的经验， 药理学，人类和动物心理物理学，以及计算机- 辅助神经生物学研究已经联合起来研究（i） 体感神经系统信息处理的变化 与实验性修改相关（长期和短期） 感觉输入与人类所经历的一致 无论是在日常生活中，还是在 创伤性损伤或疾病;（ii）躯体感觉的变化 人类临床疼痛伴随的信息处理;以及 (iii)正常人受试者和患有 口面感觉障碍，以评价 皮肤 预计这一计划的基础和临床 研究将：（一）促进相互之间的互动和合作 不同背景的调查员; ㈡支助核心 旨在促进多学科研究的设施， 体觉;（iii）促进思想交流， 仪器、技术诀窍和实验材料。

The aims of the project are (i) to identify and characterize the dynamic central nervous system adaptative mechanisms which govern the cerebral cortical response to somatic stimulation in normal subjects, and (ii) to determine their susceptability to manipulations and conditions known to be associated with orofacial sensory disorders in man. A team of investigators having extensive experience in somatosensory neurophysiology, pharmacology, human and animal psychophysics, and computer- aided neurobiological research have joined forces to study (i) the changes in somatosensory nervous system information processing associated with experimental modifications (long- and short-term) of sensory input consistent with those experienced by human subjects either in the course of everyday life or subsequent to traumatic injury or disease; (ii) the changes on somatosensory information processing accompanying clinical pain in man; and (iii) the capacity of normal human subjects and patients with orofacial sensory disorders to evaluate cutaneous motion on the skin. It is anticipated that this program of basic and clinical research will: (i) promote interactions and collaborations between investigators with different backgrounds; (ii) support core facilities designed to facilitate multidisciplinary research on somesthesia; and (iii) stimulate the exchange of ideas, instrumentation, know-how, and experimental materials.