UNIVERSITY OF PENNSYLVANIA SMELL & TASTE CENTER

本申请是对继续支持 宾夕法尼亚大学味觉研究中心 美国第一个临床研究中心 对化学感官的研究。 本中心提供 资源和科学的重点，为跨学科的临床和 基础研究涉及到理解，诊断， 治疗和管理的患者的嗅觉和 味觉障碍 数据来自国家门诊医疗 护理调查显示，1975年和1976年的总和为435，000人， 访问医生的办公室发生在其中一个主要的介绍 顺应性在本质上是化学感应的，这个中心是其中之一。 少数几个致力于理解和 治疗有这些问题的患者。 主 中心的行政办公室和诊断设施 位于大学医院内， 宾夕法尼亚 中心实验室位于学校内 医学，牙科医学和兽医学，以及 在费城退伍军人管理局医疗中心 中心的新核心设施，其中中心的 控制环境室和人体空气稀释嗅觉仪 作为该中心的主要地点， 人体研究，并定位在邻近临床 耳鼻咽喉科和人类学系的设施 通信，神经外科， 牙科医学和语言和听力中心。 这个主要 位置促进我们的中心和这些之间的直接互动 以及医院内的其他部门。 该中心目前 建立了一个基于计算机的患者登记处， 设施（基于临床记录、标准化摄入量 面试，医疗和感官评价），提供一个 丰富的数据库的病因学研究的化学感觉 疾病，其自然史，临床表现，以及 对治疗的反应。 在未来五年，我们将进一步 扩展和分析我们的核心患者数据库，并继续我们的 发展嗅觉诊断的研究计划 神经内分泌因素对嗅觉的影响 功能 此外，我们将启动新的计划，（a）低 神经组织的强激光生物刺激，包括 嗅神经上皮外植体，（B）神经解剖学 条件化学感觉厌恶的底物，（c） 抑郁症和味觉功能障碍之间的关系，以及 (d)味觉加工的脑干机制

This application is a request for continued support of the University of Pennsylvania Smell and Taste Research Center, the first Clinical Research Center in the United State devoted solely to the study of the chemical senses. This Center provides the resources and scientific focus for interdisciplinary clinical and fundamental research related to the understanding, diagnosis, treatment, and management of patients with olfactory and gustatory disorders. Data from the National Ambulatory Medical Care Survey suggest that, for 1975 and 1976 combined, 435,000 visits to physicians'offices occurred in which a major presenting compliant was chemosensory in nature, and this Center is one of the few national institutions devoted to understanding and treating patients with these problems. The primary administrative offices and diagnostic facilities of the Center are located within the Hospital of the University of Pennsylvania. Center laboratories are located within the Schools of Medicine, Dental Medicine, and Veterinary Medicine, as well as in the Veterans Administration Medical Center of Philadelphia. The new Core Facility of the Center, in which the Center's controlled environment room and human air-dilution olfactometer are located, serves as the primary location for the Center's human studies, and is positioned adjacent to the clinical facilities of the Department of Otorhinolaryngology and Human Communication, the Department of Neurosurgery, the Department of Dental Medicine, and the Speech and Hearing Center. This prime location fosters direct interactions between our Center and these and other departments within the Hospital. The Center has now established a computer-based registry of patients studied in our facility (based upon clinical records, standardized intake interviews, and medical and sensory evaluations), providing a rich data base for the study of the etiology of chemosensory disorders, their natural history, clinical manifestations, and response to therapy. During the next five years we will further expand and analyze our core patient data base and continue our research programs on the development of olfactory diagnostic tests and the influences of neuroendocrine factors on olfactory function. In addition, we will initiate new programs on (a) low intensity laser biostimulation of neural tissue, including olfactory neuroepithelial explants, (b) neuroanatomical substrates of conditioned chemosensory aversions, (c) the relation between depressive illness and taste dysfunction, and (d) brainstem mechanisms of gustatory processing.