CENTRAL MECHANISMS--CELLULAR GENERATORS OF EVOKED RESPONSES

脑干听觉诱发电位(BAEP)是对瞬变的反应 声刺激，并反映听神经细胞的活动 和脑干。因为它可以从头部的表面测量， 脑干听觉诱发电位提供了对低位听觉系统功能的无创性监测。 尽管脑干听觉诱发电位在临床上被常规使用，但细胞机制通过 它是由什么产生的，目前还不清楚。我们的目标是开发一种 基于细胞水平的CAT BAEP的生成模型。 为了实现这一目标，我们建议通过以下方式对潜在油田的产量进行建模 单独的放电单元。我们将制定一个细胞模型来描述 一个放电的神经元如何产生跨膜电流，以及一个 Head模型来描述由这些因素产生的势能分布 洋流。这些模型将针对CAT实现；细胞模型将是 为各种听觉脑干神经元实施。的可用值 在实现中将使用单元格和头部模型参数，并且 将进行实验以确定其余参数值。 已知电流源产生的电势分布 将测量麻醉猫的头部。头部模型参数值 将被调整，以使从头模型计算的电势符合 测量。个体听觉放电产生的电位 脑干神经元将使用尖峰触发的方法进行测量 平均；单元模型参数值将被调整，以使电位 使用电池和头部模型计算的结果与测量的电势相匹配。一个 BAEP的整体理论将放在临床和研究应用上 比目前明显的基础上要好得多，并将建议主办 新的实用用途。

The brainstem auditory evoked potential (BAEP) is a response to a transient acoustic stimulus, and reflects the activity of cells in the auditory nerve and brainstem. Because it can be measured from the surface of the head, the BAEP provides a noninvasive monitor of lower auditory system function. Although the BAEP is routinely used clinically, the cellular mechanisms by which it is generated are not yet understood. Our goal is to develop a model for the generation of the cat BAEP based at the cellular level. Toward that goal, we propose to model the production of potential fields by individual discharging cells. We will formulate a cell model to describe how transmembrane currents are generated by a discharging neuron, and a head model to describe the potential distribution produced by those currents. The models will be implemented for cat; the cell model will be implemented for various auditory brain-stem neurons. Available values for cell and head-model parameters will be used in the implementations, and experiments will be performed to determine the remaining parameter values. Potential distributions produced by known current sources placed in the heads of anesthetized cats will be measured; head-model parameter values will be adjusted so that potentials calculated from the head model fit the measurements. Potentials produced by individual discharging auditory brainstem neurons will be measured using the method of spike-triggered averaging; cell-model parameter values will be adjusted so that potentials calculated using the cell and head models match measured potentials. An overall theory for the BAEP will place clinical and research applications on a far sounder basis than is obvious at present and will suggest hosts of new practical uses.