MAGNESIUM DEFICIENCY--NEONATAL HYPOCALCEMIA IN DIABETIC MOTHERS' INFANTS

该提案建立在我们对钙和镁的长期研究基础上 在围产期和糖尿病妊娠的稳态。是 旨在检查胰岛素治疗中婴儿的钙镁代谢 依赖性糖尿病母亲研究的婴儿来自核心 糖尿病女性患者随机分为I组，严格对照 与第二组，习惯控制;和第三组，晚入组的受试者。在 根据本发明的建议，将糖尿病母亲的婴儿进一步随机化， 在分娩时分为两组，一组给予肌内镁 硫酸盐和一个未处理的。要研究的假设是镁 缺乏是糖尿病婴儿低钙血症的主要机制 母亲，因此在临床中预防性镁给药 试验将预防这类婴儿的新生儿高钙血症。我们假设 出生时随机接受硫酸镁治疗的婴儿 血清镁、钙、甲状旁腺激素等 12、24和72小时龄时的1，25-二羟维生素D浓度， 与随机分配不接受硫酸镁的婴儿相比。以来 新生儿期的低镁血症和低钙血症可能与 脑电图异常，手足抽搐，抽搐， 心脏紊乱，由于新生儿的传统治疗 低钙血症（即钙盐）是导致许多潜在的 并发症，出生时给予镁可能被证明是安全的， 钙治疗的简单替代品。本研究还将 考虑到新生儿窒息的主要混杂变量， 早熟，并允许确定镁的贡献 新生儿低钙血症。

The proposal builds upon our long-term studies of calcium and magnesium homeostasis in the perinatal period and the diabetic pregnancy. It is designed to examine calcium-magnesium metabolism in infants in insulin dependent diabetic mothers. Infants studied are derived from the Core Clinical Trial of diabetic women randomized into Group I, strict control versus Group II, customary control; and Group III, late entry subjects. In the present proposal, infants of diabetic mothers are further randomized at the time of delivery into-two groups, one given intramuscular magnesium sulfate and one untreated. The hypothesis to be studied is that magnesium deficiency is the major mechanism for hypocalcemia in infants of diabetic mothers, and therefore prophylactic magnesium administration in a clinical trial will prevent neonatal hypercalcemia in such infants. We hypothesize that infants randomized to magnesium sulfate at birth will have higher serum magnesium, calcium, parathyroid hormone, and similar 1,25-dihydroxyvitamin D concentrations at 12, 24 and 72 hours of age when compared with infants randomized to receive no magnesium sulfate. Since hypomagnesemia and hypocalcemia in the neonatal period may be associated with electroencephalographic abnormalities, tetany, convulsions, and cardiac disturbances, and since traditional treatment of neonatal hypocalcemia (i.e. calcium salts) is responsible for many potential complications, magnesium administration at birth could prove to be a safe, simple alternative to calcium therapy. The present study also will take into account major confounding variables of neonatal asphyxia and prematurity, and allow the determination of the contribution of magnesium deficiency to neonatal hypocalcemia.