Graphite Furnace Atomic Absorption Spectrometry for Sizing Nanoparticles

石墨炉原子吸收光谱法测定纳米颗粒尺寸

基本信息

项目摘要

The aim of the project is the development of a robust, direct and rapid method for the size determination of metal nanoparticles using graphite furnace atomic absorption spectrometry (GFAAS). The new method will provide reliable results on the size and size distribution of nanoparticles (NPs) in polydisperse suspensions, particularly for the lower nanoparticle size range. The focus is therefore on the development of a reproducible method for size detection and simultaneous concentration determination by means of GFAAS. Here, three crucial aspects will be addressed: 1. Investigation and optimization of the atomization of NPs in the graphite furnace; 2. The development of calibration strategies for size and concentration correlation; and 3. Investigation of the robustness of the method on the basis of complex, real samples. For the first sub-goal, it is important to investigate the kinetics and thermodynamics of the atomization of NPs as a function of concentration and size. For this purpose, the actual temperature curve in the graphite furnace will be recorded in-situ during the atomization phase. Thereby, amongst other parameters the so-called "appearance temperature" of the signals can be determined, from which activation energies can be calculated and the kinetic order of the atomization can be derived. These theoretical findings then serve the second sub-goal, the development of an optimal analytical calibration strategy for both particle size determination and metal concentration. Furthermore, a mathematical method for the deconvolution of signals from polydisperse suspensions will be developed and optimized in order to obtain a rapid method for the size distribution of metal nanoparticles in suspensions. In the third part of the project, more complex samples as well as real samples are to be investigated in which both a heterogeneous size distribution and heteroaggregates may occur. The robustness and possibly limits of the method are determined. The successfully developed and validated method will allow a direct, simple and fast sizing of even very small nanoparticles of real samples, which is difficult or impossible to access with other methods. In addition, the method is based on a different physical principle compared to the techniques of NP analysis proposed in the literature, such as single-particle mass spectrometry or light scattering methods. Thus, the successful project will also make a significant contribution to the analytical quality assurance of nanoparticle analysis on the way to reliable and standardized methods.
该项目的目的是开发一种使用石墨炉原子吸收光谱法(GFAAS)测定金属纳米颗粒尺寸的稳健,直接和快速的方法。新方法将提供可靠的结果的大小和大小分布的纳米粒子(NPs)在多分散悬浮液,特别是对于较低的纳米粒子尺寸范围。因此,重点是开发一种可重复的方法,用于尺寸检测和同时通过GFAAS测定浓度。在这里,三个关键方面将得到解决:1。纳米粒子在石墨炉中的原子化研究与优化; 2.开发尺寸和浓度相关性的校准策略; 3.基于复杂的真实的样品研究方法的耐用性。对于第一个子目标,重要的是研究作为浓度和尺寸的函数的NP的雾化的动力学和热力学。为此目的,在原子化阶段期间将现场记录石墨炉中的实际温度曲线。因此,除了其他参数之外,可以确定信号的所谓的“出现温度”,由此可以计算活化能并且可以导出雾化的动力学顺序。这些理论研究结果,然后服务于第二个子目标,一个最佳的分析校准策略的粒度测定和金属浓度的发展。此外,将开发和优化用于从多分散悬浮液中解卷积信号的数学方法,以获得悬浮液中金属纳米颗粒的尺寸分布的快速方法。在项目的第三部分,将调查更复杂的样品以及真实的样品,其中可能出现不均匀的粒度分布和不均匀的聚集体。确定了该方法的耐用性和可能的限度。成功开发和验证的方法将允许直接,简单和快速的尺寸甚至非常小的纳米颗粒的真实的样品,这是很难或不可能获得与其他方法。此外,与文献中提出的NP分析技术(如单粒子质谱法或光散射法)相比,该方法基于不同的物理原理。因此,该项目的成功也将为纳米颗粒分析的分析质量保证做出重大贡献,以实现可靠和标准化的方法。

项目成果

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Professorin Dr. Kerstin Leopold其他文献

Professorin Dr. Kerstin Leopold的其他文献

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{{ truncateString('Professorin Dr. Kerstin Leopold', 18)}}的其他基金

Developing new Nanogold-based Test Strip for Environmental and Bio-Monitoring of Mercury (HG) Traces - NANOTEHG -
开发新的基于纳米金的测试条,用于汞 (HG) 痕量的环境和生物监测 - NANOTEHG -
  • 批准号:
    317741991
  • 财政年份:
    2016
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Direct detection of silver nano particles in biological and environmental samples
直接检测生物和环境样品中的银纳米颗粒
  • 批准号:
    281446113
  • 财政年份:
    2015
  • 资助金额:
    --
  • 项目类别:
    Research Grants
Analysis of traces of precious metals in soils
土壤中痕量贵金属分析
  • 批准号:
    236178858
  • 财政年份:
    2013
  • 资助金额:
    --
  • 项目类别:
    Research Grants

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The Unique Bioinorganic Chemistry of the Formation of Hydroxyaluminosilicates: A Case to Support a New Graphite Furnace Atomic Absorption Spectrometer
羟基铝硅酸盐形成的独特生物无机化学:支持新型石墨炉原子吸收光谱仪的案例
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    2008
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Graphite furnace atomic absorption spectrophotometer
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    346038-2007
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    2006
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Graphite furnace atomic adsorption system (GFAAS) for assessment of water quality
用于水质评估的石墨炉原子吸附系统(GFAAS)
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    2005
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MRI: Acquisition Of A Gas Chromatograph/Mass Spectrometer And Graphite Furnace Atomic Absorption Spectrophotometer To Facilitate The Kanawha River Project.
MRI:采购气相色谱仪/质谱仪和石墨炉原子吸收分光光度计以促进卡纳瓦河项目。
  • 批准号:
    0115918
  • 财政年份:
    2001
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Direct measurement of aluminum transport across the plasma membrane of plant cells using accelerator mass spectroscopy (AMS) and graphite furnace atomic absorption spectrophotometry (GFAAS)
使用加速器质谱 (AMS) 和石墨炉原子吸收分光光度法 (GFAAS) 直接测量铝在植物细胞质膜上的传输
  • 批准号:
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  • 财政年份:
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    Collaborative Project Grants (H)
Direct measurement of aluminum transport across the plasma membrane of plant cells using accelerator mass spectroscopy (AMS) and graphite furnace atomic absorption spectrophotometry (GFAAS)
使用加速器质谱 (AMS) 和石墨炉原子吸收分光光度法 (GFAAS) 直接测量铝在植物细胞质膜上的传输
  • 批准号:
    181325-1995
  • 财政年份:
    1996
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    --
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    Collaborative Project Grants (H)
Direct measurement of aluminum transport across the plasma membrane of plant cells using accelerator mass spectroscopy (AMS) and graphite furnace atomic absorption spectrophotometry (GFAAS)
使用加速器质谱 (AMS) 和石墨炉原子吸收分光光度法 (GFAAS) 直接测量铝在植物细胞质膜上的传输
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    181325-1995
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    1995
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Acquisition of a Graphite Furnace/Flame Atomic Absorption Spectrophotometer for a Paleoceanography Laboratory
为古海洋学实验室购置石墨炉/火焰原子吸收分光光度计
  • 批准号:
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