UNIV OF PA CLINICAL SMELL & TASTE RESEARCH CENTER

本申请书是对加州大学继续提供支持的请求 宾夕法尼亚州第一临床气味与味道研究中心 美国研究中心专门致力于研究 化学感官。该中心提供资源和科学焦点 跨学科的临床和基础研究，与 慢性阻塞性肺疾病患者的认识、诊断、治疗和管理 嗅觉和味觉功能障碍。来自国家移动电话公司的数据 医疗保健调查显示，1975年和1976年加起来，有435,000人 对医生办公室的访问中，一个主要的演示 投诉本质上是化学感觉的，我们的中心是为数不多的 国家机构致力于了解和治疗慢性阻塞性肺疾病患者 这些问题。主要行政办公室和诊断 该中心的设施位于大学医院内 宾夕法尼亚州。中心实验室位于以下学校内 医学、牙科医学和兽医，以及 费城退伍军人管理局医疗中心。新的核心 中心的设施，中心的受控环境室 和人体空气稀释嗅觉仪所处的位置，作为主要 中心的人体研究的位置，并直接定位 毗邻医院内科的临床设施 耳鼻咽喉科和人类传播学系 神经外科，牙科医学系，语言和听力 中心。这一黄金地段促进了我们中心之间的直接互动 以及医院内的这些部门和其他部门。该中心现已拥有 建立了在我们设施中研究的患者的计算机登记 (基于临床记录、标准化的入院访谈和体检 和感官评价)，为研究 化学感觉障碍的病因学、自然病史、临床 症状和对治疗的反应。在接下来的五年，我们 计划在我们的三个主要项目领域继续学习(发展 诊断测试；嗅电生理学；糖尿病中的糖接受)， 以及在下列领域开发新项目：(A)生物化学和 味觉、唾液和分泌过程的生物物理学，(B) 口干症的病理生理学，以及(C)神经内分泌调节 嗅觉敏感度。

This application is a request for continued support of the University of Pennsylvania Clinical Smell and Taste Research Center, the first Clinical Research Center in the United States devoted solely to the study of the chemical senses. This Center provides the resources and scientific focus for interdisciplinary clinical and fundamental research related to the understanding, diagnosis, treatment and management of patients with olfactory and gustatory dysfunctions. Data from the National Ambulatory Medical Care Survey suggest that, for 1975 and 1976 combined, 435,000 visits to physicians' offices occurred in which a major presenting complaint was chemosensory in nature, and our Center is one of the few national institutions devoted to understanding and treating patients with these problems. The primary administrative offices and diagnostic facilities of the center are located within the Hospital of the University of Pennsylvania. Center laboratories are located within the Schools of Medicine, Dental Medicine, and Veterinary Medicine, as well as in the Veterans Administration Medical Center of Philadelphia. The new Core Facility of the Center, in which the Center's controlled environment room and human air-dilution olfactometer are located, serves as the primary location for the Center's human studies, and is positioned directly adjacent to the clinical facilities of the Department of Otorhinolaryngology and Human Communication, the Department of Neurosurgery, the Department of Dental Medicine, and the Speech and Hearing Center. This prime location fosters direct interactions between our Center and these and other departments within the Hospital. The Center has now established a computer-based registry of patients studied in our facility (based upon clinical records, standardized intake interviews, and medical and sensory evaluations), providing a rich data base for the study of the etiology of chemosensory disorders, their natural history, clinical manifestations, and response to therapy. During the next five years, we plan to continue studies in our three major project areas (development of diagnostic tests; olfactory electrophysiology; glucoreception in diabetes), as well as to develop new projects in the areas of (a) the biochemistry and biophysics of taste, saliva, and secretory processes, (b) the pathophysiology of Xerostomia, and (c) the neuroendocrine modulation of olfactory sensitivity.