SYNCHROTRON X-RAY MICROPROBE FACILITY

建议运营一个使用高能的生物技术研究中心 用于示踪的国家同步辐射光源(NSLS)产生的X射线 多个生物医学领域的元素分析。独一无二的高X射线 来自NSLS的强度将被用作X射线微探测器的基础 该设施将能够提供高度极化的光子流 在一个大小为2 mm x的黑子中大约10到15个光子/平方厘米/秒 2 mm。使用高分辨率电子和光子光谱仪 元素周期表中几乎所有元素的多元素检测 在灵敏度接近十亿分之一重量的情况下是可能的 每件样品在5分钟或更短的时间内。一个二维的 消磁系统将用于提供20个或更多的聚焦光点 较少，具有类似的检测灵敏度。该系统的性质 将进行调查以确定最终的敏感度和空间 可以获得的分辨率。将进行循环研究 将该技术与其他分析方法进行比较，并演示 它的独特之处。将对选定的生物医学主题进行研究 在合作的基础上走出去。

It is proposed to operate a Biotechnology Research Center using high-energy x-rays produced by the National Synchrotron Light Source (NSLS) for trace element analysis in a number of biomedical fields. The uniquely high x-ray intensity from the NSLS will be used as the basis of an X-Ray Microprobe Facility which will be able to provide a highly polarized photon flux of about 10 to the 15 photons/square centimeters/sec in a spot of size 2 mm x 2mm. With use of high resolution electron and photon spectrometers multielement detection for essentially all elements in the periodic table will be possible with sensitivities close to one part per billion by weight in times of 5 minutes or less for each sample. A two-dimensional demagnification system will be used to provide focussed spots of 20 Mum or less with similar detection sensitivities. The properties of this system will be investigated to determine the ultimate sensitivities and spatial resolutions that can be obtained. Round-robin studies will be carried out to compare this technique with other analytical methods and to demonstrate its unique features. Studies on selected biomedical topics will be carried out on a collaborative basis.