HARVARD CENTER FOR THE STUDY OF KIDNEY DISEASE

这项建议是一项涉及调查人员的合作努力， 哈佛医学院的基础和临床部门 及其四个主要的教学和研究附属机构（布里格姆和 妇女医院、贝斯以色列医院、 马萨诸塞州总医院（MGH）和乔斯林糖尿病 联合发展中心（JDC）寻求支持，以建立一个机构间 多学科肾脏中心致力于全面的 糖尿病肾病的治疗方法 的重点 在这一倡议中有三个方面：1）吸引新科学家 专业知识，深入研究基本的分子，细胞， 糖尿病肾损伤的生理机制; 2） 利用各组成机构方案的优势， 建立有意义的和不受限制的机构间， 跨学科合作研究计划;及（3） 将这些基础研究举措扩展到及时和创新的 发病机制的临床和流行病学研究， 肾病的治疗和预防 代谢紊乱 几项具体的基础和临床研究 糖尿病肾病的研究已经得到资助， 进展;参与这些研究的研究人员同意 分享他们的设施、方法和经验， 充分参与拟议的肾脏中心的活动， 包括其计划的教学和研究会议，每年 研讨会和广泛的实验室和临床培训计划。 我们相信，这个拟议中的中心将促进 加速获得一般领域的知识， 糖尿病和其他肾脏疾病，从而有助于 改善病人的护理。

This proposal, a collaborative effort involving investigators in the basic and clinical departments at Harvard Medical School (HMS) and four of its major teaching and research affilates (Brigham and Women's Hospital (BWH), Beth Israel Hospital (BIH), Massachusetts General Hospital (MGH), and Joslin Diabetes Center (JDC), seeks support to establish an inter-institutional mulitdisciplinary Kidney Center devoted to a comprehensive understanding of nephropathy in diabetes mellitus. The emphases in this initiative are threefold; 1) to attract new scientific expertise to the intensive study of the basic molecular, cellular and physiological mechanisms of kidney injury in diabetes; 2) to exploit the strengths of the component institutional programs by establishing meaningful and unrestricted inter-institutional, interdisciplinary collaborative research initiatives; and 3) to extend these basic research initiatives to timely and innovative clinical and epidemiological studies of the pathogenesis, treatment and prevention of the nephropathy of this common metabolic disorder. Several specific basic and clinical research studies of diabetic nephropathy are already funded and in progress; the investigators involved in these studies have agreed to share their facilities, approaches and experience and will participate fully in the activities of the proposed Kidney Center, including its planned teaching and research conferences, annual symposia and extensive laboratory and clinical training programs. It is our belief that this proposed Center will foster an acceleration in the acquisition of knowledge in the general area of diabetic and other renal diseases and thereby contribute to improved care of patients.