Rational design of genetic circuits that respond to transient signals

具有可预测和强大行为的基因电路有望带来前所未有的环境和经济效益。然而，在能够常规地从一组标准化的生物部件中构建出生命设备之前，还有很多工作要做-这是合成生物学家的目标。通过研究自然遗传开关电路如何响应瞬态信号，该项目旨在揭示一套设计规则，可用于构建和控制专用的遗传网络和途径。该项目的结果有望为合成生物学家提供更多的分子工具。

Engineered genetic circuits with predictable and robust behaviour promise unprecedented environmental and economic benefits. Yet much work remains to be done before living devices can routinely be built from a standarised set of biological parts - the goal of synthetic biologists. By studying how natural genetic switch circuits respond to transient signals, this project aims to uncover a set of design rules which could be used to construct and control purpose-built genetic networks and pathways. The results of this project are expected to add to the molecular tookit available to synthetic biologists.