CRC/PE FOR THE STUDY OF ALZHEIMER'S DISEASE

虽然最近已经进行了大量的工作，但 儿童认知功能障碍的临床和生物学特征 然而，人们对精神症状的关注却很少。 在拟建的克利夫兰大学医院/凯斯韦斯特 后备大学(UHC/CWRU)阿尔茨海默病临床研究 中心(ACRC)，我们将描述认知和精神病学 一组AD患者的症状，跟随他们 纵向上，并探索变化之间的关系 在生命和死亡中肾上腺素能和5-羟色胺能标志物 临床特点。ACRC的目标是为 更好地理解认知的生物学基础 和AD的行为表现，这将导致更好的 诊断和治疗方法。 这一目标将通过六个核心来实现：临床、 临床药理学、神经影像、神经病理学、数据 管理和分析，以及行政。核心将会 作为ACRC调查人员的资源，以及 UHC/CWRU的其他调查人员。全面的诊断 认知和精神疾病的治疗方法 阿尔茨海默病的表现显然需要生物学和 行为方面。其中包括五个具体的研究项目 在建议中：1)5-羟色胺能和 去甲肾上腺素能标记物在血小板中的作用 肾上腺素能和5-羟色胺能系统对皮质醇的调节 3)死后分泌物和糖皮质激素受体数量 皮质、肾上腺素能和5-羟色胺能结合的改变 部位，4)蓝斑病理描述和 中缝核团；5)血脑神经控制的研究 障碍监管。此外，机制特别是 包括在ACRC中以评估新的研究建议 由UHC/CWRU调查人员生成。

Although considerable work has been performed recently on the clinical and biological features of the cognitive impairment of AD, little attention has been paid to the psychiatric symptoms. In the proposed University Hospitals of Cleveland/Case Western Reserve University (UHC/CWRU) Alzheimer Clinical Research Center (ACRC), we will characterize cognitive and psychiatric symptoms of a population of AD patients, follow them longitudinally, and explore the relationships between alterations in adrenergic and serotonergic markers in life and in death with the clinical features. The goal of this ACRC is to contribute to a better understanding of the biological basis of the cognitive and behavioral manifestations of AD, which will lead to better diagnostic and therapeutic approaches. This goal will be accomplished through six cores: Clinical, Clinical Pharmacology Neuroimaging, Neuropathology, Data Management and Analysis, and Administrative. The cores will serve as a resource for investigators in the ACRC, as well as other investigators at UHC/CWRU. A comprehensive diagnostic and therapeutic approach to the cognitive and psychiatric manifestations of AD obviously requires both biological and behavioral aspects. Five specific research projects are included in the proposal: 1) biochemical assessment of serotonergic and noradrenergic markers in blood platelets, 2) the role of adrenergic and serotonergic systems in the regulation of cortisol secretion and glucocorticoid receptor number, 3) post mortem alterations in cortical, adrenergic, and serotonergic binding sites, 4) description of the pathology of the locus coeruleus and raphe nucleii, and 5) studies of the neural control of blood-brain barrier regulation. In addition, mechanisms are specifically included in the ACRC to evaluate new research proposals generated by UHC/CWRU investigators.