OLFACTORY MODEL OF BRAIN AGING

拟议的研究试图利用广泛的形态 嗅觉、边缘和基底前脑之间的功能联系 啮齿动物的结构为衰老研究开发有利的模型 在哺乳动物的中枢神经系统中。边缘的神经化学变化 和胆碱能的基底前脑结构，与嗅觉系统 是否有直接关联已被认为是与 记忆和认知障碍，有时会随着年龄的增长而发生，以及 这些结构和连接中更严重的萎缩性变化可能 解释了阿尔茨海默病的衰弱症状。一个相互关联的 一系列心理物理，行为，电生理， 建议进行内分泌、生化和免疫组织化学分析。 为了检查这些结构和连接的老化变化的影响 关于嗅觉信息加工的认知和记忆方面。 通过这些分析，希望为以后的研究奠定基础。 脑老化的细胞和神经化学机制。

The proposed research seeks to capitalize upon the extensive morphological and functional interconnections among olfactory, limbic and basal forebrain structures in rodents to develop an advantageous model for studies of aging in the mammalian central nervous system. Neurochemical changes in limbic and cholinergic basal forebrain structures with which the olfactory system is directly connected have been implicated as etiological factors in mnemonic and cognitive impairments that sometimes occur with aging, and more severe atrophic changes in these structures and connections may account for debilitating symptoms of Alzheimer's disease. An interrelated series of psychophysical, behavioral, electrophysiological, endocrinological, biochemical and immunohistochemical analyses is proposed to examine the effects of aging changes in these structures and connections on cognitive and mnemonic aspects of olfactory information processing. Through these analyses we hope to lay the groundwork for research on cellular and neurochemical mechanisms of brain aging.