Investigating pathways of lipoglycan formation in the bacterial cell wall

本项目旨在研究分枝杆菌和棒状杆菌的复杂细胞壁是如何组装的。该项目将利用遗传、生物化学和先进的分析方法相结合，研究关键细胞壁组分合成的各个步骤，并了解这些组分的组装如何与细菌生长协调。这项研究的重要成果将是关于调节具有重要生物技术，兽医和医学意义的细菌生长过程的详细信息，以及可能在所有细菌中保存的细胞壁合成机制的信息。

This project aims to investigate how the complex cell walls of Mycobacteria and Corynebacteria are assembled. The project will utilise a combination of genetic, biochemical and advanced analytical approaches to investigate individual steps in the synthesis of key cell wall components and understand how the assembly of these components is coordinated with bacterial growth. Important outcomes of this research will be detailed information on processes that regulate the growth of bacteria with important biotechnology, veterinary and medical significance, as well as information on mechanisms of cell wall synthesis that may be conserved in all bacteria.