Gastrointestinal hormones: linking insulin dysregulation and laminitis

该项目旨在通过研究两种关键激素Ghrelin和GLP-2，以及特定的基因突变是否导致胰岛素失调来确定疾病的最早致病因素。利用创新的方法，该项目将能够识别处于危险中的动物并确定新的治疗策略。从长远来看，改进的疾病治疗和预防将减少与痛苦和常常是致命的并存疾病相关的痛苦。

This project aims to identify the earliest pathogenic factors of disease by investigating two key hormones, ghrelin and GLP-2, and whether a specific genetic mutation underlies insulin dysregulation. Using innovative approaches the project will enable the identification of at-risk animals and pinpoint novel treatment strategies. In the long term improved disease treatment and prevention will reduce the suffering associated with painful and often lethal co-morbidities.