Understanding equine incretins: a novel approach to laminitis prevention

足部炎是马的一种致残性足部疾病，它会带来巨大的经济和社会成本。最近的研究表明，持续的高胰岛素浓度会引发足板炎，而高胰岛素水平是由一种叫做肠促胰岛素的激素的过度释放引起的。本项目旨在确定肠促胰岛素及其受体在引起马胰岛素分泌异常中的作用。马肠促胰岛素受体的分布将首次被描述，肠促胰岛素受体结合的后果将被表征。了解马肠促胰岛素生物学可能导致新的治疗板炎。

Laminitis is a crippling foot disease in horses which incurs significant economic and social costs. Recent studies have shown that persistently high insulin concentrations can trigger laminitis, and that high insulin levels are caused by the excessive release of hormones called incretins. This project aims to determine the role of incretins and their receptors in causing abnormal equine insulin secretion. The distribution of equine incretin receptors will be described for the first time, and the consequences of incretin receptor binding will be characterised. Understanding equine incretin biology may lead to novel therapies for laminitis.