HISTOCOMPATIBILITY ANTIGENS OF THE MOUSE

这个项目的长期目标是调查 小鼠的细胞同种异体抗原系统，特别强调 主要组织相容性基因复合体(MHC)。这证明了 MHC在免疫反应的调节中起着关键作用 观察到人类与老鼠共享一个密切相关的系统 MHC研究的临床意义。MHC是一种 由紧密相连的一群人控制的基因调控系统 基因。该项目的一个目标是分析人类的精细遗传结构。 MHC使用遗传和免疫学程序，以识别和 描述组件的结构和功能属性 部分MHC，并调查MHC的组件 MHC调节免疫反应。人们已经了解了很多关于 使用选择性繁殖的免疫反应的机制 基因上亲缘关系密切的小鼠品系 MHC内部的分歧。 其他涉及免疫遗传学研究的实验也在计划之中。 可诱发皮肤的次要组织相容性基因座H-3的特性 移植物排斥反应。它特别有意义，因为它可能会受到监管 通过一个复杂的基因系统。将使用免疫遗传学对其进行研究 程序。

The long term objective of this project has been the investigation of cellular alloantigen systems of the mouse with particular emphasis on the major histocompatibility gene complex (MHC). The demonstration that the MHC plays a key part in the regulation of immune responses and the observation that humans share a closely related system with mice lends clinical relevance to the investigation of the MHC. The MHC is a genetically regulated system controlled by a cluster of closely-linked genes. A goal of the project is to analyze the fine genetic structure of the MHC using genetic and immunological procedures, to identify and characterize the structural and functional properties of the component parts of the MHC and to investigate the manner in which the components of the MHC regulate immune responsiveness. Much has been learned about the mechanics of the immune response through the use of selectively bred strains of mice which are genetically closely related except for defined differences within the MHC. Other experiments are planned which involve the study of the immunogenetic properties of H-3, a minor histocompatibility locus which can evoke skin graft rejections. It is of particular interest because it may be regulated by a complex gene system. It will be investigated using immunogenetic procedures.