RELATIONSHIP OF AGING, FEVER AND CELL MEDIATED IMMUNITY

这项研究提案的目标是确定(A)如何推进 年龄使发热反应减弱，(B)发热反应是否完整 与细胞免疫的完整性有关，以及(C)是否 缺锌等营养因素会导致钝性发热 与年龄相关的反应。 老年人的传染病患病率较高，并患有 感染性并发症的发病率和死亡率更高。此外， 老年感染患者具有不典型的临床表现 感染，尤其是发烧。发烧经常钝化或消失。 在这群人中感染的存在。研究方案 试图研究这一现象并了解其发病机制 机制。 该项目将通过以下方式评估小鼠和老年鼠的发烧反应 注射从幼鼠腹腔巨噬细胞中提取的内源性热原 还有老老鼠。发烧反应也将与体外试验相关 检测细胞介导的免疫功能。最后，小白鼠和老白鼠 将导致缺锌，并评估内源性发热反应 热源。

The objectives of this research proposal are to determine (a) how advancing age diminishes fever response, (b) whether the integrity of fever response is related to the integrity of cell-mediated immunity, and (c) whether nutritional factors such as zinc deficiency contribute to blunted fever responses associated with age. Elderly persons have a higher prevalence of infectious diseases and suffer greater morbidity and mortality from infectious complications. Moreover, elderly patients with infections have atypical clinical manifestations of infections, particularly fever. Fever is frequently blunted or absent in the presence of infection in this population. The research proposal attempts to investigate this phenomenon and understand its pathogenetic mechanism. The project will evaluate fever responses in young and old mice by injecting endogenous pyrogen extracted from peritoneal macrophages of young and old mice. The fever responses will also be correlated with in vitro testing of cell-mediated immune functions. Finally, young and old mice will be made zinc deficient and evaluated for fever responses to endogenous pyrogens.