HISTOCOMPATIBILITY ANTIGENS OF THE MOUSE

该项目的长期目标是调查 小鼠的细胞同种异体抗原系统，特别强调 主要组织相容性基因复合体（MHC）。 示威者说， MHC在免疫应答的调节中起关键作用， 人类与老鼠有着密切相关的系统， 与MHC研究的临床相关性。 所述MHC是 由一群紧密相连的 基因. 该项目的一个目标是分析 MHC使用遗传和免疫程序，以确定和 表征组件的结构和功能特性 部分的MHC和调查的方式，其中组件的 MHC调节免疫应答。 我们已经了解了很多关于 免疫反应的机制，通过使用选择性繁殖的 小鼠品系，其在遗传上密切相关，除了定义的 MHC内的差异。 其他实验计划涉及免疫遗传学的研究， H-3的性质，一个次要的组织相容性位点，可以引起皮肤 移植排斥反应 它之所以特别令人感兴趣，是因为它可能受到监管， 一个复杂的基因系统。 将使用免疫遗传学 程序.

The long term objective of this project has been the investigation of cellular alloantigen systems of the mouse with particular emphasis on the major histocompatibility gene complex (MHC). The demonstration that the MHC plays a key part in the regulation of immune responses and the observation that humans share a closely related system with mice lends clinical relevance to the investigation of the MHC. The MHC is a genetically regulated system controlled by a cluster of closely-linked genes. A goal of the project is to analyze the fine genetic structure of the MHC using genetic and immunological procedures, to identify and characterize the structural and functional properties of the component parts of the MHC and to investigate the manner in which the components of the MHC regulate immune responsiveness. Much has been learned about the mechanics of the immune response through the use of selectively bred strains of mice which are genetically closely related except for defined differences within the MHC. Other experiments are planned which involve the study of the immunogenetic properties of H-3, a minor histocompatibility locus which can evoke skin graft rejections. It is of particular interest because it may be regulated by a complex gene system. It will be investigated using immunogenetic procedures.