PHYSIOLOGY OF MOSQUITO HOST-SEEKING

蚊子无疑是人类最重要的昆虫媒介之一 和动物病原体。这些昆虫找到脊椎动物的能力 寄主和以其血液为食是它们作为媒介的基本作用。确实有 然而，当蚊子寻找寄主和取血被禁止的时候 内生性的。这项研究计划将研究人的生理学 卵子发生过程中的内源性抑制，一直持续到卵子发生之后 产卵会发生。先前的研究表明，卵巢 产生一种体液物质，启动另一种激素的释放 这抑制了寻找寄主的行为。利用显微外科技术，建议的 实验将尝试确定抑制剂的释放位置 以及对这次释放的控制。各种因素之间的关系 生理状态和寻找寄主的抑制也将被检查。一个 对蚊子行为的内源性调节的理解将是 控制程序的基础是使用昆虫自身的激素来 操纵它的行为。

Mosquitoes are undoubtedly among the most important insect vectors of human and animal pathogens. The ability of these insects to find a vertebrate host and feed on its blood is basic to their role as a vector. There are times, however, when mosquito host-seeking and blood-feeding are inhibited endogenously. This research proposal will investigate the physiology of the endogenous inhibition occurring during oogenesis that lasts until after oviposition takes place. Prior studies have demonstrated that the ovaries produce a humoral substance which initiates the release of another hormone that inhibits host-seeking. Using techniques of microsurgery, the proposed experiments will attempt to identify the site of release of the inhibitor and the control of this release. The relationships between various physiological states and host-seeking inhibition will also be examined. An understanding of the endogenous regulation of mosquito behavior would be the basis for a control program using the insect's own hormones to manipulate its behavior.