GENETIC AND STRUCTURAL ORGANIZATION OF HUMAN IA

在人类中，由HLA-D区编码的多个B细胞同种抗原系统， 主要组织相容性复合体已被定义。 这些往往是 称为Ia抗原。 重组DNA研究表明， 因为存在六个不同的Ia基因座，尽管生物化学和遗传学研究 只正式展示了其中三种的表达方式。 的 Ia基因座编码的分子显示高度多态性， 同种异型之间的多个氨基酸序列差异。 这 多态性在功能上表现为不同的同种异型 确定免疫反应的差异。 此外，许多疾病 表现出自身免疫特征，如类风湿性关节炎， 多发性硬化症与特定的Ia同种异型有关。 我们希望 分析Ia分子之间变异性的分子基础， 生物化学和重组DNA技术。 更具体地说，我们希望 问以下问题：有多少不同的Ia分子可以单独 个人快递？ 不同Ia的分子关系是什么 同一个人体内的分子 分子间的关系是什么 个体间Ia分子的差异吗 我们相信这些研究会帮助我们 了解Ia分子如何调节免疫反应， 疾病易感性

In man multiple B cell alloantigenic systems encoded by the HLA-D region of the major histocompatibility complex have been defined. These are often referred to as Ia antigens. Recombinant DNA studies suggest that as many as six distinct Ia loci exist, although biochemical and genetic studies have only formally demonstrated the expression of three of them. The molecules encoded by the Ia loci display a high degree of polymorphism due to multiple amino acid sequence differences among allotypes. This polymorphism is manifested functionally in that different allotypes determine differences in immune responsiveness. In addition many diseases that display autoimmune characteristics such as rheumatoid arthritis and multiple sclerosis are associated with particular Ia allotypes. We wish to analyze the molecular basis of variability among Ia molecules using biochemical and recombinant DNA techniques. More specifically we wish to ask the following questions: How many different Ia molecules can a single individual express? What are the molecular relationships of different Ia molecules within the same individual? What are the molecular relationships of Ia molecules between individuals? We believe these studies will help us to understand how Ia molecules regulate immune responsiveness and determine disease susceptibility.